| Literature DB >> 29343432 |
Savit Prabhu1, Ian A Cockburn1, Carola G Vinuesa2.
Abstract
Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers.Mesh：
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Year: 2018 PMID： 29343432 DOI： 10.1016/j.immuni.2018.01.002
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745