Jari Heiskanen1, Anna-Maija Tolppanen2, Risto P Roine3,4, Juha Hartikainen5,6, Mikko Hippeläinen5,7, Heikki Miettinen5,8, Janne Martikainen9. 1. Kuopio University Hospital and Research Centre for Comparative Effectiveness and Patient Safety (RECEPS), School of Pharmacy, University of Eastern Finland, Kuopio Campus, Yliopistonranta 1 C, PO Box 1627, Kuopio FI-70211, Finland. 2. Research Centre for Comparative Effectiveness and Patient Safety (RECEPS), School of Pharmacy, University of Eastern Finland, Kuopio, Finland. 3. Research Centre for Comparative Effectiveness and Patient Safety (RECEPS), Department of Health and Social Management, University of Eastern Finland, Kuopio, Finland. 4. Kuopio University Hospital and Helsinki University Hospital, Kuopio, Finland. 5. School of Medicine, University of Eastern Finland, Kuopio, Finland. 6. Heart Center, Kuopio University Hospital, Kuopio, Finland. 7. Heart Surgery, Heart Center, Kuopio University Hospital, Kuopio, Finland. 8. Department of Cardiology, Heart Center, Kuopio University Hospital, Kuopio, Finland. 9. School of Pharmacy, Pharmacoeconomics and Outcomes Research Unit (PHORU), University of Eastern Finland, Kuopio, Finland.
Abstract
AIMS: Patient-centred outcomes can be measured with different instruments. We compared the performance of two health-related quality-of-life (HRQoL) measures, EQ-5D and 15D, in patients undergoing elective coronary artery bypass grafting (CABG). METHODS AND RESULTS: Patients who were admitted for elective CABG in Kuopio University Hospital Finland in 2012-14 and had completed both instruments concurrently as part of the admission process (n = 182). Follow-up was conducted by postal survey 12 months after the CABG operation. The validity, agreement, and responsiveness to change of both instruments were examined. The mean baseline HRQoL index scores obtained by the EQ-5D and the 15D were 0.795 and 0.859, respectively (P < 0.001 for difference). The agreement between instruments was poor (Spearman's rho = 0.449; P < 0.001). Observed ceiling effects at baseline for the EQ-5D and 15D were 31.9 and 4.4%, respectively. EQ-5D was able to discriminate distinct Canadian Cardiovascular Society groups. During the 1-year follow-up, clinically important improvement was observed in 39.6 and 53.3% of patients with the EQ-5D and the 15D, respectively. However, with the 15D, the number of operated patients required to produce one additional quality-adjusted life year (QALY) was more than twice as high compared with the EQ-5D. CONCLUSION: EQ-5D and 15D do not appear to be interchangeable when patient-centred outcomes in CABG patients are assessed. The EQ-5D seems to have better discriminative power and known-group validity, whereas the 15D is more sensitive to change over time. These instruments lead to significantly different estimates concerning the number of QALYs gained. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: Patient-centred outcomes can be measured with different instruments. We compared the performance of two health-related quality-of-life (HRQoL) measures, EQ-5D and 15D, in patients undergoing elective coronary artery bypass grafting (CABG). METHODS AND RESULTS: Patients who were admitted for elective CABG in Kuopio University Hospital Finland in 2012-14 and had completed both instruments concurrently as part of the admission process (n = 182). Follow-up was conducted by postal survey 12 months after the CABG operation. The validity, agreement, and responsiveness to change of both instruments were examined. The mean baseline HRQoL index scores obtained by the EQ-5D and the 15D were 0.795 and 0.859, respectively (P < 0.001 for difference). The agreement between instruments was poor (Spearman's rho = 0.449; P < 0.001). Observed ceiling effects at baseline for the EQ-5D and 15D were 31.9 and 4.4%, respectively. EQ-5D was able to discriminate distinct Canadian Cardiovascular Society groups. During the 1-year follow-up, clinically important improvement was observed in 39.6 and 53.3% of patients with the EQ-5D and the 15D, respectively. However, with the 15D, the number of operated patients required to produce one additional quality-adjusted life year (QALY) was more than twice as high compared with the EQ-5D. CONCLUSION: EQ-5D and 15D do not appear to be interchangeable when patient-centred outcomes in CABG patients are assessed. The EQ-5D seems to have better discriminative power and known-group validity, whereas the 15D is more sensitive to change over time. These instruments lead to significantly different estimates concerning the number of QALYs gained. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Anni Pohjola; Elias Oulasvirta; Risto P Roine; Harri P Sintonen; Ahmad Hafez; Päivi Koroknay-Pál; Hanna Lehto; Mika Niemelä; Aki Laakso Journal: Acta Neurochir (Wien) Date: 2021-04-16 Impact factor: 2.216