Romain Glâtre1, Héloïse De Kermadec1, Issam Abd Alsamad2, Cécile Badoual3,4,5, Anne Gauthier1, Lydia Brugel1, Claire Parra1, André Coste1,6,7,8,9, Virginie Prulière-Escabasse1,6,7, Emilie Bequignon1,6,7,8,9. 1. Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Centre Hospitalier Intercommunal de Créteil, Créteil, France. 2. Department of Pathology, Centre Hospitalier Intercommunal de Créteil, Créteil, France. 3. INSERM U970 Paris Cardiovascular Research Center (PARCC), Paris, France. 4. Department of Pathology, Université Paris Descartes, Sorbonne Paris-Cité, Paris, France. 5. Hôpital Européen Georges Pompidou (HEGP), Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France. 6. Université Paris-Est, Faculté de Médecine, Créteil, France. 7. INSERM U955, Créteil, France. 8. Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Hôpital Henri Mondor, Assistance Publique Hôpitaux de Paris (AP-HP), Créteil, France. 9. Department of Otolaryngology - Head and Neck Surgery, Centre National de la Recherche Scientifique (CNRS), Hôpital Intercommunal, Créteil, France.
Abstract
BACKGROUND: Sinonasal exophytic papillomas are rare. The multifocal form, florid papillomatosis, has not been yet described in literature. We report on the clinical features and the management of the different forms of exophytic papilloma. METHODS: A retrospective study was conducted that included all patients with exophytic papilloma treated in our center over the past 12 years. We recorded clinical presentation, treatments, recurrences, pathology (p16 expression and human papillomavirus [HPV] status). RESULTS: We included 13 patients with a mean follow-up of 5 years. The main location of exophytic papilloma was the anterior part of the septum. Lesions were multifocal in 3 patients corresponding to florid papillomatosis. The main treatment was surgery. Cases of HPV-11 or HPV-6 were present in all forms of exophytic papilloma (dysplasia in 4 cases). Late recurrences occurred in 3 patients (2 patients with florid papillomatosis) over a period of 3 years. CONCLUSION: Exophytic papilloma has 2 clinical presentations: localized and diffuse. Patients with florid papillomatosis should be monitored closely as recurrence seems to be frequent.
BACKGROUND: Sinonasal exophytic papillomas are rare. The multifocal form, florid papillomatosis, has not been yet described in literature. We report on the clinical features and the management of the different forms of exophytic papilloma. METHODS: A retrospective study was conducted that included all patients with exophytic papilloma treated in our center over the past 12 years. We recorded clinical presentation, treatments, recurrences, pathology (p16 expression and human papillomavirus [HPV] status). RESULTS: We included 13 patients with a mean follow-up of 5 years. The main location of exophytic papilloma was the anterior part of the septum. Lesions were multifocal in 3 patients corresponding to florid papillomatosis. The main treatment was surgery. Cases of HPV-11 or HPV-6 were present in all forms of exophytic papilloma (dysplasia in 4 cases). Late recurrences occurred in 3 patients (2 patients with florid papillomatosis) over a period of 3 years. CONCLUSION:Exophytic papilloma has 2 clinical presentations: localized and diffuse. Patients with florid papillomatosis should be monitored closely as recurrence seems to be frequent.