Graziano Onder1, Silvia Giovannini2, Federica Sganga2, Ester Manes-Gravina2, Eva Topinkova3,4, Harriet Finne-Soveri5, Vjenka Garms-Homolová6, Anja Declercq7, Henriëtte G van der Roest8, Pálmi V Jónsson9, Hein van Hout8, Roberto Bernabei2. 1. Department of Gerontology, Neuroscience and Orthopedics, Centro Medicina dell'Invecchiamento, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168, Rome, Italy. graziano.onder@unicatt.it. 2. Department of Gerontology, Neuroscience and Orthopedics, Centro Medicina dell'Invecchiamento, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168, Rome, Italy. 3. Department of Geriatrics and Gerontology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. 4. Faculty of Health and Social Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic. 5. National Institute for Health and Welfare, Helsinki, Finland. 6. Department of Economics and Law, HTW Berlin University of Applied Sciences, Berlin, Germany. 7. LUCAS & Center for Sociological Research, KU Leuven, Leuven, Belgium. 8. Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Institute, VU University Medical Center, Amsterdam, The Netherlands. 9. Department of Geriatrics, Landspitali University Hospital, Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
Abstract
AIM: Drugs may interact with geriatric syndromes by playing a role in the continuation, recurrence or worsening of these conditions. Aim of this study is to assess the prevalence of interactions between drugs and three common geriatric syndromes (delirium, falls and urinary incontinence) among older adults in nursing home and home care in Europe. METHODS: We performed a cross-sectional multicenter study among 4023 nursing home residents participating in the Services and Health for Elderly in Long-TERm care (Shelter) project and 1469 home care patients participating in the Identifying best practices for care-dependent elderly by Benchmarking Costs and outcomes of community care (IBenC) project. Exposure to interactions between drugs and geriatric syndromes was assessed by 2015 Beers criteria. RESULTS: 790/4023 (19.6%) residents in the Shelter Project and 179/1469 (12.2%) home care patients in the IBenC Project presented with one or more drug interactions with geriatric syndromes. In the Shelter project, 288/373 (77.2%) residents experiencing a fall, 429/659 (65.1%) presenting with delirium and 180/2765 (6.5%) with urinary incontinence were on one or more interacting drugs. In the IBenC project, 78/172 (45.3%) participants experiencing a fall, 80/182 (44.0%) presenting with delirium and 36/504 (7.1%) with urinary incontinence were on one or more interacting drugs. CONCLUSION: Drug-geriatric syndromes interactions are common in long-term care patients. Future studies and interventions aimed at improving pharmacological prescription in the long-term care setting should assess not only drug-drug and drug-disease interactions, but also interactions involving geriatric syndromes.
AIM: Drugs may interact with geriatric syndromes by playing a role in the continuation, recurrence or worsening of these conditions. Aim of this study is to assess the prevalence of interactions between drugs and three common geriatric syndromes (delirium, falls and urinary incontinence) among older adults in nursing home and home care in Europe. METHODS: We performed a cross-sectional multicenter study among 4023 nursing home residents participating in the Services and Health for Elderly in Long-TERm care (Shelter) project and 1469 home care patients participating in the Identifying best practices for care-dependent elderly by Benchmarking Costs and outcomes of community care (IBenC) project. Exposure to interactions between drugs and geriatric syndromes was assessed by 2015 Beers criteria. RESULTS: 790/4023 (19.6%) residents in the Shelter Project and 179/1469 (12.2%) home care patients in the IBenC Project presented with one or more drug interactions with geriatric syndromes. In the Shelter project, 288/373 (77.2%) residents experiencing a fall, 429/659 (65.1%) presenting with delirium and 180/2765 (6.5%) with urinary incontinence were on one or more interacting drugs. In the IBenC project, 78/172 (45.3%) participants experiencing a fall, 80/182 (44.0%) presenting with delirium and 36/504 (7.1%) with urinary incontinence were on one or more interacting drugs. CONCLUSION: Drug-geriatric syndromes interactions are common in long-term care patients. Future studies and interventions aimed at improving pharmacological prescription in the long-term care setting should assess not only drug-drug and drug-disease interactions, but also interactions involving geriatric syndromes.
Authors: Sara Salini; Silvia Giovannini; Marcello Covino; Christian Barillaro; Nicola Acampora; Ester Manes Gravina; Claudia Loreti; Francesco Paolo Damiano; Francesco Franceschi; Andrea Russo Journal: Diagnostics (Basel) Date: 2022-05-13
Authors: Carlos Durantez-Fernández; Begoña Polonio-López; José L Martín-Conty; Clara Maestre-Miquel; Antonio Viñuela; Raúl López-Izquierdo; Laura Mordillo-Mateos; Cristina Jorge-Soto; Martín Otero-Agra; Michele Dileone; Joseba Rabanales-Sotos; Francisco Martín-Rodríguez Journal: J Pers Med Date: 2022-04-14