Ohad Gluck1, Yossi Mizrachi2, Jacob Bar2, Giulia Barda2. 1. Department of Obstetrics and Gynecology, E. Wolfson Medical Center, Holon, Sackler School of Medicine, Tel Aviv University, Halochamim St, 62, 58100, Holon, Israel. ohadgluck@gmail.com. 2. Department of Obstetrics and Gynecology, E. Wolfson Medical Center, Holon, Sackler School of Medicine, Tel Aviv University, Halochamim St, 62, 58100, Holon, Israel.
Abstract
PURPOSE: To assess the effect of advanced maternal age on the obstetrics and neonatal outcome of twin pregnancies. METHODS: A retrospective study of 716 dichorionic-diamniotic twin pregnancies delivered at our institute. The study population was divided into two groups: women aged 35-39 years (group A, n = 142) and women aged ≥ 40 years (Group B, n = 48). The control group consisted of women younger than 35 years (group C, n = 516). RESULTS: The rate of cesarean section (CS) was significantly higher among women older than 35 years compared to the control group (A 76.8% and B 87.5% vs C 65.7%, P = 0.001). Women older than 35 years were also at higher risk for developing hypertensive disorders (A 7.0%, B 14.6%, vs C 5.4%, P = 0.04). On multivariate regression analysis, maternal age was found to be independently associated with a higher rate of CS (odds ratio vs reference group C: group A 1.6, 95% CI 1.08-2.6; group B 3.2, 95% CI 1.3-7.8). There was no difference between the groups in the rate of neonatal complications. CONCLUSION: Women with twin pregnancy, older than 35 years, have a significantly higher rate of CS and hypertensive disorder. This rate increases with maternal age, with no increased rate of neonatal complications.
PURPOSE: To assess the effect of advanced maternal age on the obstetrics and neonatal outcome of twin pregnancies. METHODS: A retrospective study of 716 dichorionic-diamniotic twin pregnancies delivered at our institute. The study population was divided into two groups: women aged 35-39 years (group A, n = 142) and women aged ≥ 40 years (Group B, n = 48). The control group consisted of women younger than 35 years (group C, n = 516). RESULTS: The rate of cesarean section (CS) was significantly higher among women older than 35 years compared to the control group (A 76.8% and B 87.5% vs C 65.7%, P = 0.001). Women older than 35 years were also at higher risk for developing hypertensive disorders (A 7.0%, B 14.6%, vs C 5.4%, P = 0.04). On multivariate regression analysis, maternal age was found to be independently associated with a higher rate of CS (odds ratio vs reference group C: group A 1.6, 95% CI 1.08-2.6; group B 3.2, 95% CI 1.3-7.8). There was no difference between the groups in the rate of neonatal complications. CONCLUSION:Women with twin pregnancy, older than 35 years, have a significantly higher rate of CS and hypertensive disorder. This rate increases with maternal age, with no increased rate of neonatal complications.
Authors: Ana Bouzaglou; Ines Aubenas; Hind Abbou; Stephanie Rouanet; Marie Carbonnel; Paul Pirtea; Jean Marc Bernard Ayoubi Journal: Front Med (Lausanne) Date: 2020-05-27