Literature DB >> 29339959

Medical Cannabis, a Beneficial High in Treatment of Blepharospasm? An Early Observation.

Phillip M Radke1, Ali Mokhtarzadeh1, Michael S Lee1,2,3, Andrew R Harrison1,4.   

Abstract

The objective of this study was to observe the effect of medical cannabis in benign essential blepharospasm (BEB) as an adjunct to botulinum toxin. A retrospective chart review was performed on patients certified for medical cannabis use for BEB from September 2015 to May 2016. Patient demographics and responses, cannabis history, and severity indices were collected. Ten patients were certified for medical cannabis use. Five met the inclusion criteria, which was any patient with a diagnosis of BEB receiving standard botulinum toxin treatment who had started medical cannabis treatment by a registered distributor within the state, and was contactable by phone. Four patients discontinued use. Three out of four patients (75%) reported symptomatic improvement. Medical cannabis is an accepted therapy for muscle spastic disorders. Its potential as an adjunctive therapy for BEB remains unknown, and further investigations would be of benefit.

Entities:  

Keywords:  Blepharospasm; cannabis; marijuana; muscle spasm

Year:  2017        PMID: 29339959      PMCID: PMC5764009          DOI: 10.1080/01658107.2017.1318150

Source DB:  PubMed          Journal:  Neuroophthalmology        ISSN: 0165-8107


  20 in total

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Authors:  Marta Duran; Eulàlia Pérez; Sergio Abanades; Xavier Vidal; Cristina Saura; Margarita Majem; Edurne Arriola; Manel Rabanal; Antoni Pastor; Magí Farré; Neus Rams; Joan-Ramon Laporte; Dolors Capellà
Journal:  Br J Clin Pharmacol       Date:  2010-11       Impact factor: 4.335

2.  Prevalence of primary blepharospasm in Sardinia, Italy: a service-based survey.

Authors:  Giovanni Cossu; Alessandra Mereu; Marcello Deriu; Maurizio Melis; Andrea Molari; Giannina Melis; Laura Minafra; Tiziana Pisano; Carlo Cianchetti; Enzo Ortu; Gianfranco Sau; Isidoro Aiello; Miriana Fresu; Maria Giovanna Marrosu; Paolo Contu
Journal:  Mov Disord       Date:  2006-11       Impact factor: 10.338

3.  A randomized, placebo-controlled, crossover trial of cannabis cigarettes in neuropathic pain.

Authors:  Barth Wilsey; Thomas Marcotte; Alexander Tsodikov; Jeanna Millman; Heather Bentley; Ben Gouaux; Scott Fishman
Journal:  J Pain       Date:  2008-04-10       Impact factor: 5.820

4.  Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up.

Authors:  J P Zajicek; H P Sanders; D E Wright; P J Vickery; W M Ingram; S M Reilly; A J Nunn; L J Teare; P J Fox; A J Thompson
Journal:  J Neurol Neurosurg Psychiatry       Date:  2005-12       Impact factor: 10.154

5.  Health-related quality of life in blepharospasm or hemifacial spasm.

Authors:  J Reimer; K Gilg; A Karow; J Esser; G H Franke
Journal:  Acta Neurol Scand       Date:  2005-01       Impact factor: 3.209

Review 6.  The pharmacologic and clinical effects of medical cannabis.

Authors:  Laura M Borgelt; Kari L Franson; Abraham M Nussbaum; George S Wang
Journal:  Pharmacotherapy       Date:  2013-02       Impact factor: 4.705

7.  Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study.

Authors:  C Vaney; M Heinzel-Gutenbrunner; P Jobin; F Tschopp; B Gattlen; U Hagen; M Schnelle; M Reif
Journal:  Mult Scler       Date:  2004-08       Impact factor: 6.312

8.  Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial.

Authors:  Ronald J Ellis; Will Toperoff; Florin Vaida; Geoffrey van den Brande; James Gonzales; Ben Gouaux; Heather Bentley; J Hampton Atkinson
Journal:  Neuropsychopharmacology       Date:  2008-08-06       Impact factor: 7.853

9.  Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial.

Authors:  Jody Corey-Bloom; Tanya Wolfson; Anthony Gamst; Shelia Jin; Thomas D Marcotte; Heather Bentley; Ben Gouaux
Journal:  CMAJ       Date:  2012-05-14       Impact factor: 8.262

Review 10.  Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review.

Authors:  Shaheen E Lakhan; Marie Rowland
Journal:  BMC Neurol       Date:  2009-12-04       Impact factor: 2.474

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  1 in total

Review 1.  Cannabinoids and dystonia: an issue yet to be defined.

Authors:  Marcello Mario Mascia; Daniele Carmagnini; Giovanni Defazio
Journal:  Neurol Sci       Date:  2019-12-17       Impact factor: 3.307

  1 in total

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