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Literature DB >> 29337966

Drug development: Allosteric inhibitors hit USP7 hard.

Wei Zhang¹, Sachdev S Sidhu¹.

Abstract

Entities: Gene

Mesh：

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Year: 2018 PMID： 29337966 DOI： 10.1038/nchembio.2557

Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040

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11 in total

Review 1. Modulation of the p53/MDM2 interplay by HAUSP inhibitors.

Authors: Omid Tavana; Wei Gu
Journal: J Mol Cell Biol Date: 2017-02-01 Impact factor: 6.216

2. USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms.

Authors: Alexandra Pozhidaeva; Gabrielle Valles; Feng Wang; Jian Wu; David E Sterner; Phuong Nguyen; Joseph Weinstock; K G Suresh Kumar; Jean Kanyo; Dennis Wright; Irina Bezsonova
Journal: Cell Chem Biol Date: 2017-10-19 Impact factor: 8.116

3. Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10.

Authors: Wei Zhang; Maria A Sartori; Taras Makhnevych; Kelly E Federowicz; Xiaohui Dong; Li Liu; Satra Nim; Aiping Dong; Jingsong Yang; Yanjun Li; Dania Haddad; Andreas Ernst; Dirk Heerding; Yufeng Tong; Jason Moffat; Sachdev S Sidhu
Journal: J Mol Biol Date: 2017-06-03 Impact factor: 5.469

4. A strategy for modulation of enzymes in the ubiquitin system.

Authors: Andreas Ernst; George Avvakumov; Jiefei Tong; Yihui Fan; Yanling Zhao; Philipp Alberts; Avinash Persaud; John R Walker; Ana-Mirela Neculai; Dante Neculai; Andrew Vorobyov; Pankaj Garg; Linda Beatty; Pak-Kei Chan; Yu-Chi Juang; Marie-Claude Landry; Christina Yeh; Elton Zeqiraj; Konstantina Karamboulas; Abdellah Allali-Hassani; Masoud Vedadi; Mike Tyers; Jason Moffat; Frank Sicheri; Laurence Pelletier; Daniel Durocher; Brian Raught; Daniela Rotin; Jianhua Yang; Michael F Moran; Sirano Dhe-Paganon; Sachdev S Sidhu
Journal: Science Date: 2013-01-03 Impact factor: 47.728

5. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells.

Authors: Frédéric Colland; Etienne Formstecher; Xavier Jacq; Céline Reverdy; Cécile Planquette; Susan Conrath; Virginie Trouplin; Julie Bianchi; Vasily N Aushev; Jacques Camonis; Alessandra Calabrese; Catherine Borg-Capra; Wolfgang Sippl; Vincent Collura; Guillaume Boissy; Jean-Christophe Rain; Philippe Guedat; Rémi Delansorne; Laurent Daviet
Journal: Mol Cancer Ther Date: 2009-08-11 Impact factor: 6.261

6. Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Authors: Andrew P Turnbull; Stephanos Ioannidis; Wojciech W Krajewski; Adan Pinto-Fernandez; Claire Heride; Agnes C L Martin; Louise M Tonkin; Elizabeth C Townsend; Shane M Buker; David R Lancia; Justin A Caravella; Angela V Toms; Thomas M Charlton; Johanna Lahdenranta; Erik Wilker; Bruce C Follows; Nicola J Evans; Lucy Stead; Cristina Alli; Vladislav V Zarayskiy; Adam C Talbot; Alexandre J Buckmelter; Minghua Wang; Crystal L McKinnon; Fabienne Saab; Joanna F McGouran; Hannah Century; Malte Gersch; Marc S Pittman; C Gary Marshall; Tony M Raynham; Mary Simcox; Lorna M D Stewart; Sheila B McLoughlin; Jaime A Escobedo; Kenneth W Bair; Christopher J Dinsmore; Tim R Hammonds; Sunkyu Kim; Sylvie Urbé; Michael J Clague; Benedikt M Kessler; David Komander
Journal: Nature Date: 2017-10-18 Impact factor: 49.962

7. Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.

Authors: Wei Zhang; Ben A Bailey-Elkin; Robert C M Knaap; Baldeep Khare; Tim J Dalebout; Garrett G Johnson; Puck B van Kasteren; Nigel J McLeish; Jun Gu; Wenguang He; Marjolein Kikkert; Brian L Mark; Sachdev S Sidhu
Journal: PLoS Pathog Date: 2017-05-18 Impact factor: 6.823

Review 8. Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets.

Authors: Lynn Bedford; James Lowe; Lawrence R Dick; R John Mayer; James E Brownell
Journal: Nat Rev Drug Discov Date: 2010-12-10 Impact factor: 84.694

9. System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

Authors: Wei Zhang; Kuen-Phon Wu; Maria A Sartori; Hari B Kamadurai; Alban Ordureau; Chong Jiang; Peter Y Mercredi; Ryan Murchie; Jicheng Hu; Avinash Persaud; Manjeet Mukherjee; Nan Li; Anne Doye; John R Walker; Yi Sheng; Zhenyue Hao; Yanjun Li; Kevin R Brown; Emmanuel Lemichez; Junjie Chen; Yufeng Tong; J Wade Harper; Jason Moffat; Daniela Rotin; Brenda A Schulman; Sachdev S Sidhu
Journal: Mol Cell Date: 2016-03-03 Impact factor: 17.970