Virginie Kieffer1, Mathilde P Chevignard1, Georges Dellatolas2, Stephanie Puget3, Frederic Dhermain4, Jacques Grill5, Dominique Valteau-Couanet5, Christelle Dufour5. 1. a Rehabilitation Department for children with acquired neurological injury , Saint Maurice Hospitals , Saint Maurice , France. 2. b University Paris Sud, University Paris Descartes , Villejuif , France. 3. c Department of neurosurgery , Necker-Enfants Malades Hospital , Paris , France. 4. d Département de radiothérapie , Gustave Roussy , Villejuif , France. 5. e Département de Cancérologie de l'Enfant et de l'Adolescent , Gustave Roussy , Villejuif , France.
Abstract
PURPOSE: To investigate intellectual and situation-based social outcome and educational achievement in adult survivors of childhood medulloblastoma and analyse factors influencing outcome Methods: We collected demographic, medical and cognitive data, and social and educational outcome at a mean time since the end of treatments of 14.9 years in 58 adults, aged 19-35 years, consecutively treated in a single cancer center between 1989 and 2005. RESULTS: Ten survivors had severe intellectual disability, 12 were still studying, 23 had a regular employment and 13 were unemployed. Full Scale Intellectual Quotient, assessed 6.6 years after the end of treatments, ranged from 46 to 131. It was strongly associated with educational achievement and significantly lower in patients who experienced postoperative cerebellar mutism, and when parental education level was low. CONCLUSION: These factors should be systematically considered at diagnosis in order to offer adequate and timely assessments and interventions.
PURPOSE: To investigate intellectual and situation-based social outcome and educational achievement in adult survivors of childhood medulloblastoma and analyse factors influencing outcome Methods: We collected demographic, medical and cognitive data, and social and educational outcome at a mean time since the end of treatments of 14.9 years in 58 adults, aged 19-35 years, consecutively treated in a single cancer center between 1989 and 2005. RESULTS: Ten survivors had severe intellectual disability, 12 were still studying, 23 had a regular employment and 13 were unemployed. Full Scale Intellectual Quotient, assessed 6.6 years after the end of treatments, ranged from 46 to 131. It was strongly associated with educational achievement and significantly lower in patients who experienced postoperative cerebellar mutism, and when parental education level was low. CONCLUSION: These factors should be systematically considered at diagnosis in order to offer adequate and timely assessments and interventions.
Authors: Linda Dirven; Ralf Luerding; Dagmar Beier; Elisabeth Bumes; Christiane Reinert; Clemens Seidel; Matteo Mario Bonsanto; Michael Bremer; Stefan Rieken; Stephanie E Combs; Ulrich Herrlinger; Corinna Seliger; Holger Kuntze; Regine Mayer-Steinacker; Annette Dieing; Claudius Bartels; Oliver Schnell; Astrid Weyerbrock; Sabine Seidel; Oliver Grauer; Minou Nadji-Ohl; Frank Paulsen; Michael Weller; Wolfgang Wick; Peter Hau Journal: J Neurooncol Date: 2020-05-04 Impact factor: 4.130
Authors: Mirella Baroni; Gabriela D A Guardia; Xiufen Lei; Adam Kosti; Mei Qiao; Tesha Landry; Karl Mau; Pedro A F Galante; Luiz O F Penalva Journal: Cells Date: 2021-12-25 Impact factor: 6.600
Authors: Tiina M Remes; Emma Hovén; Niina Ritari; Heli Pohjasniemi; Riina Puosi; Pekka M Arikoski; Mikko O Arola; Päivi M Lähteenmäki; Tuula R I Lönnqvist; Marja K Ojaniemi; V Pekka Riikonen; Kirsti H Sirkiä; Satu Winqvist; Heikki M J Rantala; Marika Harila; Arja H Harila-Saari Journal: Neurooncol Pract Date: 2021-01-22