Younes Najafian 1 , Zahra M Khorasani 2 , Mona N Najafi 3 , Shokouh S Hamedi 4 , Marjan Mahjour 1 , Zohre Feyzabadi 1 Show Affiliations »
Abstract
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BACKGROUND: Diabetic foot ulcer (DFU ) is one of the most common complications of diabetic patients . Mostly, non-healing DFU leads to infection, gangrene, amputation and even death. High costs and poor healing of the wounds need a new treatment such as alternative medicine. So, the aim of this study was to evaluate the efficacy of Aloe vera/ Plantago major gel (Plantavera gel ) in healing of DFU. METHODS: Forty patients with DFU enrolled in a double-blind randomized clinical trial. The patients who were randomly assigned into the intervention group (n = 20), received topical Plantavera gel in addition to the routine cares, whereas the patients in the control group (n = 20), received topical Placebo gel in addition to the routine cares. Intervention was done twice a day for 4 weeks in the both groups. Photography and an evaluation of DFU healing were conducted by a checklist and then were scored at baseline and at the end of each week. The collected data was analyzed by SPSS software. RESULTS: At the end of the study, there was a significant difference between the two groups in terms of total ulcer score (P<0.001) and Plantavera gel significantly reduced the ulcer surface comparing with the control group (P=0.039). However, there was not a significant difference between the two groups (P=0.263) in terms of the ulcer depth. During this study, no side effect was observed for Plantavera gel in the intervention group. CONCLUSION: Topical Plantavera gel seems to be an effective, cheap and safe treatment. Of course, further studies are required to confirm the properties of the wound healing of this gel. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
RCT Entities: Population
Interventions
Outcomes
BACKGROUND: Diabetic foot ulcer (DFU) is one of the most common complications of diabetic patients . Mostly, non-healing DFU leads to infection , gangrene , amputation and even death . High costs and poor healing of the wounds need a new treatment such as alternative medicine. So, the aim of this study was to evaluate the efficacy of Aloe vera / Plantago major gel (Plantavera gel) in healing of DFU. METHODS: Forty patients with DFU enrolled in a double-blind randomized clinical trial. The patients who were randomly assigned into the intervention group (n = 20), received topical Plantavera gel in addition to the routine cares, whereas the patients in the control group (n = 20), received topical Placebo gel in addition to the routine cares. Intervention was done twice a day for 4 weeks in the both groups. Photography and an evaluation of DFU healing were conducted by a checklist and then were scored at baseline and at the end of each week. The collected data was analyzed by SPSS software. RESULTS: At the end of the study, there was a significant difference between the two groups in terms of total ulcer score (P<0.001) and Plantavera gel significantly reduced the ulcer surface comparing with the control group (P=0.039). However, there was not a significant difference between the two groups (P=0.263) in terms of the ulcer depth . During this study, no side effect was observed for Plantavera gel in the intervention group. CONCLUSION: Topical Plantavera gel seems to be an effective, cheap and safe treatment. Of course, further studies are required to confirm the properties of the wound healing of this gel. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities: Disease
Species
Keywords:
Aloe vera; Diabetic foot ulcer; Plantago major; plantain; plantavera gel; ulcer healing.
Year: 2019
PMID： 29336265 DOI： 10.2174/1570163815666180115093007
Source DB: PubMed Journal: Curr Drug Discov Technol ISSN： 1570-1638