| Literature DB >> 29335549 |
Anuradha Jagadeesan1,2, Ellen D Gunnarsdóttir1, S Sunna Ebenesersdóttir1,2, Valdis B Guðmundsdóttir1,2, Elisabet Linda Thordardottir1, Margrét S Einarsdóttir1,2, Hákon Jónsson1, Jean-Michel Dugoujon3, Cesar Fortes-Lima3, Florence Migot-Nabias4,5, Achille Massougbodji6,7, Gil Bellis8, Luisa Pereira9,10,11, Gísli Másson1, Augustine Kong1, Kári Stefánsson12,13, Agnar Helgason14,15.
Abstract
A genome is a mosaic of chromosome fragments from ancestors who existed some arbitrary number of generations earlier. Here, we reconstruct the genome of Hans Jonatan (HJ), born in the Caribbean in 1784 to an enslaved African mother and European father. HJ migrated to Iceland in 1802, married and had two children. We genotyped 182 of his 788 descendants using single-nucleotide polymorphism (SNP) chips and whole-genome sequenced (WGS) 20 of them. Using these data, we reconstructed 38% of HJ's maternal genome and inferred that his mother was from the region spanned by Benin, Nigeria and Cameroon.Entities:
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Year: 2018 PMID： 29335549 DOI： 10.1038/s41588-017-0031-6
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330