Wout Füssenich1,2, Sven Hirschfeld Araujo3, Birgitt Kowald4, Allard Hosman5, Marc Auerswald3, Roland Thietje3. 1. Centre for Spinal Injuries, BG Trauma Hospital Hamburg, Hamburg, Germany. woutfussenich@gmail.com. 2. Department of Orthopedic Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands. woutfussenich@gmail.com. 3. Centre for Spinal Injuries, BG Trauma Hospital Hamburg, Hamburg, Germany. 4. Biomechanics Laboratory, BG Trauma Hospital Hamburg, Hamburg, Germany. 5. Department of Orthopedic Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands.
Abstract
STUDY DESIGN: Retrospective, single centre cohort study. OBJECTIVES: To determine factors associated with ventilator weaning success and failure in patients with acute spinal cord injury (SCI); determine length of time and attempts required to wean from the ventilator successfully and determine the incidence of pneumonia. SETTING: BG Klinikum Hamburg, Level 1 trauma centre, SCI Department, Germany. METHODS: From 2010 until 2017, 165 consecutive patients with cervical SCI, initially dependent on a ventilator, were included and weaned discontinuously via tracheal cannula. Data related to anthropometric details, neurological injury, respiratory outcomes, and weaning parameters were prospectively recorded in a database and retrospectively analysed. RESULTS: Seventy-nine percent of all patients were successfully weaned from ventilation. Average duration of the complete weaning process was 37 days. Ninety-one percent of the successfully weaned patients completed this on first attempt. Age (>56 years), level of injury (C4 and/or above), vital capacity (<1500 ml), obesity (>25 kg/m2), and chronic obstructive pulmonary disease (COPD) significantly decreased the chance of successful weaning. These factors also correlated with a higher number of weaning attempts. High level of injury, older age, and reduced vital capacity also increased the duration of the weaning process. Patients with low vital capacity and concurrent therapy with Baclofen and Dantrolene showed higher rates of pneumonia. CONCLUSIONS: We conclude that mentioned factors are associated with weaning outcome and useful for clinical recommendations and patient counselling. These data further support the complexity of ventilator weaning in the SCI population due to associated complications, therefore we recommend conducting weaning of patients with SCI on intensive or intermediate care units (ICU/IMCU) in specialised centres.
STUDY DESIGN: Retrospective, single centre cohort study. OBJECTIVES: To determine factors associated with ventilator weaning success and failure in patients with acute spinal cord injury (SCI); determine length of time and attempts required to wean from the ventilator successfully and determine the incidence of pneumonia. SETTING: BG Klinikum Hamburg, Level 1 trauma centre, SCI Department, Germany. METHODS: From 2010 until 2017, 165 consecutive patients with cervical SCI, initially dependent on a ventilator, were included and weaned discontinuously via tracheal cannula. Data related to anthropometric details, neurological injury, respiratory outcomes, and weaning parameters were prospectively recorded in a database and retrospectively analysed. RESULTS: Seventy-nine percent of all patients were successfully weaned from ventilation. Average duration of the complete weaning process was 37 days. Ninety-one percent of the successfully weaned patients completed this on first attempt. Age (>56 years), level of injury (C4 and/or above), vital capacity (<1500 ml), obesity (>25 kg/m2), and chronic obstructive pulmonary disease (COPD) significantly decreased the chance of successful weaning. These factors also correlated with a higher number of weaning attempts. High level of injury, older age, and reduced vital capacity also increased the duration of the weaning process. Patients with low vital capacity and concurrent therapy with Baclofen and Dantrolene showed higher rates of pneumonia. CONCLUSIONS: We conclude that mentioned factors are associated with weaning outcome and useful for clinical recommendations and patient counselling. These data further support the complexity of ventilator weaning in the SCI population due to associated complications, therefore we recommend conducting weaning of patients with SCI on intensive or intermediate care units (ICU/IMCU) in specialised centres.
Authors: Steven C Kirshblum; Stephen P Burns; Fin Biering-Sorensen; William Donovan; Daniel E Graves; Amitabh Jha; Mark Johansen; Linda Jones; Andrei Krassioukov; M J Mulcahey; Mary Schmidt-Read; William Waring Journal: J Spinal Cord Med Date: 2011-11 Impact factor: 1.985
Authors: J-M Boles; J Bion; A Connors; M Herridge; B Marsh; C Melot; R Pearl; H Silverman; M Stanchina; A Vieillard-Baron; T Welte Journal: Eur Respir J Date: 2007-05 Impact factor: 16.671
Authors: K Dalhoff; M Abele-Horn; S Andreas; T Bauer; H von Baum; M Deja; S Ewig; P Gastmeier; S Gatermann; H Gerlach; B Grabein; G Höffken; W V Kern; E Kramme; C Lange; J Lorenz; K Mayer; I Nachtigall; M Pletz; G Rohde; S Rosseau; B Schaaf; R Schaumann; D Schreiter; H Schütte; H Seifert; H Sitter; C Spies; T Welte Journal: Pneumologie Date: 2012-12-06
Authors: E J McCaughey; M Purcell; A N McLean; M H Fraser; A Bewick; R J Borotkanics; D B Allan Journal: Spinal Cord Date: 2015-10-13 Impact factor: 2.772
Authors: Anja Maria Raab; Gabi Mueller; Simone Elsig; Simon C Gandevia; Marcel Zwahlen; Maria T E Hopman; Roger Hilfiker Journal: J Clin Med Date: 2021-12-31 Impact factor: 4.241