Literature DB >> 2933450

Antibody-complement-mediated cytotoxicity is enhanced by ribosome-inactivating proteins.

V S Goldmacher, J Anderson, W A Blättler, J M Lambert, P D Senter.   

Abstract

The antibody-mediated cytotoxicity of complement can be increased by the ribosome-inactivating proteins gelonin and PAP-S. Treatment of human lymphoid cells that express CALLA with an anti-CALLA monoclonal antibody, J5, and then with rabbit complement, leaves about 6% of the cells alive. The same treatment in the presence of a sublethal concentration of gelonin or PAP-S leaves only about 0.02 and 0.3% of the cells alive respectively. This synergistic effect has potential implications for the in vitro elimination of malignant cells or of immunocompetent cells from bone marrow before its transplantation.

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Year:  1985        PMID： 2933450

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  5 in total

1.  In vivo administration of lymphocyte-specific monoclonal antibodies in nonhuman primates. IV. Cytotoxic effect of an anti-T11-gelonin immunotoxin.

Authors:  K A Reimann; V S Goldmacher; J M Lambert; L V Chalifoux; S B Cook; S F Schlossman; N L Letvin
Journal:  J Clin Invest       Date:  1988-07       Impact factor: 14.808

2.  An immunotoxin containing a rat IgM monoclonal antibody (Campath 1) and saporin 6: effect on T lymphocytes and hemopoietic cells.

Authors:  P L Tazzari; L Barbieri; M Gobbi; A Dinota; S Rizzi; A Bontadini; A Pession; S Tura; F Stirpe
Journal:  Cancer Immunol Immunother       Date:  1988       Impact factor: 6.968

3.  The antileukemic efficacy of an immunotoxin composed of a monoclonal anti-Thy-1 antibody disulfide linked to the ribosome-inactivating protein gelonin.

Authors:  C F Scott; V S Goldmacher; J M Lambert; R V Chari; S Bolender; M N Gauthier; W A Blättler
Journal:  Cancer Immunol Immunother       Date:  1987       Impact factor: 6.968

4.  An immunotoxin containing momordin suitable for bone marrow purging in multiple myeloma patients.

Authors:  A Dinota; L Barbieri; M Gobbi; P L Tazzari; S Rizzi; A Bontadini; A Bolognesi; S Tura; F Stirpe
Journal:  Br J Cancer       Date:  1989-09       Impact factor: 7.640

5.  Evidence that pinocytosis in lymphoid cells has a low capacity.

Authors:  V S Goldmacher; N L Tinnel; B C Nelson
Journal:  J Cell Biol       Date:  1986-04       Impact factor: 10.539
  5 in total

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