Francesca Sanguedolce1, Matteo Brunelli2, Alessandro D'amuri3, Beppe Calò4, Vito Mancini4, Giuseppe Carrieri4, Luigi Cormio4. 1. a Department of Pathology , University of Foggia , Foggia , Italy. 2. b Department of Pathology and Diagnostic , University of Verona , Verona , Italy. 3. c Anatomic Pathology , Card. G. Panico Hospital , Tricase , Italy. 4. d Department of Urology and Renal Transplantation , University of Foggia , Foggia , Italy.
Abstract
CONTEXT: The classification of flat non-neoplastic urothelial lesions has been evolved through the years in the attempt to better define a spectrum of morphologic entities with somewhat overlapping features. Differentiating these lesions is important because of differences in patient management and clinical outcome. Materials and methods and objective: A systematic review of the literature has been carried out in order to (1) assess the most striking clinical features of each lesion and (2) identify those morphological traits and immunophenotypical markers which may aid in the differential diagnosis. RESULTS AND CONCLUSION: Our results point out the importance of a proper definition of flat non-neoplastic urothelial lesions in order to predict clinical behaviour and allow tailored patient management; therefore, we attempted to construct a novel and "easy to use" algorithm for a clear, standardized and evidence-based pathological diagnosis.
CONTEXT: The classification of flat non-neoplastic urothelial lesions has been evolved through the years in the attempt to better define a spectrum of morphologic entities with somewhat overlapping features. Differentiating these lesions is important because of differences in patient management and clinical outcome. Materials and methods and objective: A systematic review of the literature has been carried out in order to (1) assess the most striking clinical features of each lesion and (2) identify those morphological traits and immunophenotypical markers which may aid in the differential diagnosis. RESULTS AND CONCLUSION: Our results point out the importance of a proper definition of flat non-neoplastic urothelial lesions in order to predict clinical behaviour and allow tailored patient management; therefore, we attempted to construct a novel and "easy to use" algorithm for a clear, standardized and evidence-based pathological diagnosis.
Authors: Francesca Sanguedolce; Magda Zanelli; Andrea Palicelli; Stefano Ascani; Maurizio Zizzo; Giorgia Cocco; Lars Björnebo; Anna Lantz; Ugo Giovanni Falagario; Luigi Cormio; Giuseppe Carrieri Journal: Int J Mol Sci Date: 2022-07-15 Impact factor: 6.208
Authors: B Calò; F Sanguedolce; F Fortunato; G Stallone; N d'Altilia; M Chirico; U Falagario; Vito Mancini; G Carrieri; L Cormio Journal: Medicine (Baltimore) Date: 2019-08 Impact factor: 1.817