Mariantonia Ferrara1,2,3, Laura Eggenschwiler1,2, Andrew Stephenson1,2, Alyssa Montieth1,2, Nakhoul Nakhoul4, Rafael Araùjo-Miranda5,6, C Stephen Foster1,2,7. 1. a Massachusetts Eye Research and Surgery Institution , Waltham , Massachusetts , USA. 2. b The Ocular Immunology and Uveitis Foundation , Waltham , Massachusetts , USA. 3. c Department of Neuroscience, Reproductive and Odontostomatological Science , Federico II University , Naples , Italy. 4. d Department of Ophthalmology, Barich Padeh Medical Center , Poriya , Israel. 5. e Faculty of Medicine in the Galilee , Bar-Ilan University , Safed , Israel. 6. f FISABIO Oftalmologia Medica , Valencia , Spain. 7. g Department of Ophthalmology , Harvard Medical School , Boston , Massachusetts , USA.
Abstract
Purpose: To describe the distribution, clinical findings, visual outcomes, treatment, and complications of children with uveitis at a tertiary referral ophthalmic center. Methods: Retrospective cohort study. We reviewed the medical records of all patients ≤16 years with uveitis referred to Massachusetts Eye Research and Surgery Institution from March 2005 to July 2016. Results: Of 286 included children, 62.24% were female. Mean age of onset was 8.4 years. The uveitis was mainly anterior (61.9%), recurrent (68.53%), bilateral (81.82%), and noninfectious (96.5%). Idiopathic cases accounted for 51.4%. The most frequent systemic association was juvenile idiopathic arthritis (34.96%). The majority of patients (78.32%) experienced complications. All patients, except one, needed systemic therapy. Conclusion: Pediatric uveitis is challenging to diagnose and manage, with frequent and potentially severe complications. Most cases were bilateral, recurrent, and idiopathic. Prompt referral to uveitis-specialized centers and an appropriate systemic therapy are mandatory for good visual outcomes.
Purpose: To describe the distribution, clinical findings, visual outcomes, treatment, and complications of children with uveitis at a tertiary referral ophthalmic center. Methods: Retrospective cohort study. We reviewed the medical records of all patients ≤16 years with uveitis referred to Massachusetts Eye Research and Surgery Institution from March 2005 to July 2016. Results: Of 286 included children, 62.24% were female. Mean age of onset was 8.4 years. The uveitis was mainly anterior (61.9%), recurrent (68.53%), bilateral (81.82%), and noninfectious (96.5%). Idiopathic cases accounted for 51.4%. The most frequent systemic association was juvenile idiopathic arthritis (34.96%). The majority of patients (78.32%) experienced complications. All patients, except one, needed systemic therapy. Conclusion:Pediatric uveitis is challenging to diagnose and manage, with frequent and potentially severe complications. Most cases were bilateral, recurrent, and idiopathic. Prompt referral to uveitis-specialized centers and an appropriate systemic therapy are mandatory for good visual outcomes.
Entities:
Keywords:
Epidemiology; immunomodulatory therapy; pediatric uveitis; uveitis; visual loss
Authors: Sheila T Angeles-Han; Mindy S Lo; Lauren A Henderson; Melissa A Lerman; Leslie Abramson; Ashley M Cooper; Miriam F Parsa; Lawrence S Zemel; Tova Ronis; Timothy Beukelman; Erika Cox; H Nida Sen; Gary N Holland; Hermine I Brunner; Andrew Lasky; C Egla Rabinovich Journal: Arthritis Care Res (Hoboken) Date: 2019-04 Impact factor: 4.794