PURPOSE: To develop, test, evaluate and apply a novel tool for the white matter fiber-based analysis of T1w/T2w ratio maps quantifying myelin content. BACKGROUND: The cerebral white matter in the human brain develops from a mostly non-myelinated state to a nearly fully mature white matter myelination within the first few years of life. High resolution T1w/T2w ratio maps are believed to be effective in quantitatively estimating myelin content on a voxel-wise basis. We propose the use of a fiber-tract-based analysis of such T1w/T2w ratio data, as it allows us to separate fiber bundles that a common regional analysis imprecisely groups together, and to associate effects to specific tracts rather than large, broad regions. METHODS: We developed an intuitive, open source tool to facilitate such fiber-based studies of T1w/T2w ratio maps. Via its Graphical User Interface (GUI) the tool is accessible to non-technical users. The framework uses calibrated T1w/T2w ratio maps and a prior fiber atlas as an input to generate profiles of T1w/T2w values. The resulting fiber profiles are used in a statistical analysis that performs along-tract functional statistical analysis. We applied this approach to a preliminary study of early brain development in neonates. RESULTS: We developed an open-source tool for the fiber based analysis of T1w/T2w ratio maps and tested it in a study of brain development.
PURPOSE: To develop, test, evaluate and apply a novel tool for the white matter fiber-based analysis of T1w/T2w ratio maps quantifying myelin content. BACKGROUND: The cerebral white matter in the human brain develops from a mostly non-myelinated state to a nearly fully mature white matter myelination within the first few years of life. High resolution T1w/T2w ratio maps are believed to be effective in quantitatively estimating myelin content on a voxel-wise basis. We propose the use of a fiber-tract-based analysis of such T1w/T2w ratio data, as it allows us to separate fiber bundles that a common regional analysis imprecisely groups together, and to associate effects to specific tracts rather than large, broad regions. METHODS: We developed an intuitive, open source tool to facilitate such fiber-based studies of T1w/T2w ratio maps. Via its Graphical User Interface (GUI) the tool is accessible to non-technical users. The framework uses calibrated T1w/T2w ratio maps and a prior fiber atlas as an input to generate profiles of T1w/T2w values. The resulting fiber profiles are used in a statistical analysis that performs along-tract functional statistical analysis. We applied this approach to a preliminary study of early brain development in neonates. RESULTS: We developed an open-source tool for the fiber based analysis of T1w/T2w ratio maps and tested it in a study of brain development.
Authors: Brian B Avants; Nicholas J Tustison; Gang Song; Philip A Cook; Arno Klein; James C Gee Journal: Neuroimage Date: 2010-09-17 Impact factor: 6.556
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Authors: Alice M Graham; Claudia Buss; Jerod M Rasmussen; Marc D Rudolph; Damion V Demeter; John H Gilmore; Martin Styner; Sonja Entringer; Pathik D Wadhwa; Damien A Fair Journal: Dev Cogn Neurosci Date: 2015-10-03 Impact factor: 6.464
Authors: Matthew F Glasser; Timothy S Coalson; Michael P Harms; Junqian Xu; Graham L Baum; Joonas A Autio; Edward J Auerbach; Douglas N Greve; Essa Yacoub; David C Van Essen; Nicholas A Bock; Takuya Hayashi Journal: Neuroimage Date: 2022-06-10 Impact factor: 7.400