Recent advances and developments on integrating nanotechnology with chemiluminescence assays.

Chemiluminescence (CL) techniques are extensively utilized for detection of analytes due to their high sensitivity, rapidity and selectivity. With the advent of nanotechnology and incorporation of the nanoparticles in the CL system has revolutionized the assays due to their unique optical and mechanical properties. Several CL-based reactions have been developed where these nanoparticle based CL sensors have evolved as excellent prospects for sensing in various analytical applications. This review article addresses the nanoparticles based CL detection system that are recently developed, the mechanisms has been summarized and the role of luminophors have been discussed. This article critically analyzes the optimal conditions for the CL detection along with quantitative assessment of the analytes. We have included the use of semiconductor nanoparticles, metal nanoparticles, graphene based nanostructures, mesoporous nanospheres, layered double hydroxides, clays for CL detection. The scope and application of these nanoscale material based CL system in various branches of science and technology including chemistry, biomedical applications, pharmaceutics, food, environmental and toxicological applications has been critically summarized.