Ana Beatriz Bozzini1, Luciana Neder2, Clovis A Silva3, Gilda Porta4. 1. Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Departamento de Pediatria, São Paulo, SP, Brazil. Electronic address: anabeatrizbozzini@gmail.com. 2. Universidade Federal do Mato Grosso (UFMT), Departamento de Clínicas, Cuiabá, MT, Brazil. 3. Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Departamento de Pediatria, São Paulo, SP, Brazil. 4. Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Programa de Pós-graduação Pediátrica, São Paulo, SP, Brazil.
Abstract
OBJECTIVE: The objective of this study was to evaluate the health-related quality of life in children and adolescents with autoimmune hepatitis. METHODS: A cross-sectional assessment with the Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) was completed for 80 patients with autoimmune hepatitis and 45 healthy controls. Demographic data, prednisone dose, disease remission state, disease severity, and abdominal pain were also evaluated. RESULTS: Based on the child self-reports, physical, emotional, school, and total scores were significantly lower in autoimmune hepatitis patients when compared with controls (p<0.05). Based on the parental reports, only the physical and total scores were significantly lower in autoimmune hepatitis patients versus controls (p<0.05). Further analysis in autoimmune hepatitis patients with abdominal pain in the last month revealed significantly lower physical, social, and total median scores (p<0.05). No differences were observed based on disease remission state or disease severity (p>0.05). Autoimmune hepatitis patients who received a prednisone dose below 0.16mg/kg/day at the time of the interview showed significantly higher physical scores than those who received a dose similar to or above 0.16mg/kg/day (87.5 [50-100] vs. 75 [15.63-100], p=0.006). CONCLUSIONS: Reduced scores in the physical, emotional, and school domains were observed in pediatric autoimmune hepatitis patients compared to control patients. Abdominal pain and corticosteroid dose negatively influenced the health-related quality of life in children and adolescents with autoimmune hepatitis.
OBJECTIVE: The objective of this study was to evaluate the health-related quality of life in children and adolescents with autoimmune hepatitis. METHODS: A cross-sectional assessment with the Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) was completed for 80 patients with autoimmune hepatitis and 45 healthy controls. Demographic data, prednisone dose, disease remission state, disease severity, and abdominal pain were also evaluated. RESULTS: Based on the child self-reports, physical, emotional, school, and total scores were significantly lower in autoimmune hepatitispatients when compared with controls (p<0.05). Based on the parental reports, only the physical and total scores were significantly lower in autoimmune hepatitispatients versus controls (p<0.05). Further analysis in autoimmune hepatitispatients with abdominal pain in the last month revealed significantly lower physical, social, and total median scores (p<0.05). No differences were observed based on disease remission state or disease severity (p>0.05). Autoimmune hepatitispatients who received a prednisone dose below 0.16mg/kg/day at the time of the interview showed significantly higher physical scores than those who received a dose similar to or above 0.16mg/kg/day (87.5 [50-100] vs. 75 [15.63-100], p=0.006). CONCLUSIONS: Reduced scores in the physical, emotional, and school domains were observed in pediatric autoimmune hepatitispatients compared to control patients. Abdominal pain and corticosteroid dose negatively influenced the health-related quality of life in children and adolescents with autoimmune hepatitis.
Authors: Thais T Fink; Heloisa H S Marques; Bruno Gualano; Livia Lindoso; Vera Bain; Camilla Astley; Fernanda Martins; Denise Matheus; Olivia M Matsuo; Priscila Suguita; Vitor Trindade; Camila S Y Paula; Sylvia C L Farhat; Patricia Palmeira; Gabriela N Leal; Lisa Suzuki; Vicente Odone Filho; Magda Carneiro-Sampaio; Alberto José S Duarte; Leila Antonangelo; Linamara R Batisttella; Guilherme V Polanczyk; Rosa Maria R Pereira; Carlos Roberto R Carvalho; Carlos A Buchpiguel; Ana Claudia L Xavier; Marilia Seelaender; Clovis Artur Silva; Maria Fernanda B Pereira; Adriana M E Sallum; Alexandra V M Brentani; Álvaro José S Neto; Amanda Ihara; Andrea R Santos; Ana Pinheiro M Canton; Andreia Watanabe; Angélica C Dos Santos; Antonio C Pastorino; Bernadette D G M Franco; Bruna Caruzo; Carina Ceneviva; Carolina C M F Martins; Danilo Prado; Deipara M Abellan; Fabiana B Benatti; Fabiana Smaria; Fernanda T Gonçalves; Fernando D Penteado; Gabriela S F de Castro; Guilherme S Gonçalves; Hamilton Roschel; Ilana R Disi; Isabela G Marques; Inar A Castro; Izabel M Buscatti; Jaline Z Faiad; Jarlei Fiamoncini; Joaquim C Rodrigues; Jorge D A Carneiro; Jose A Paz; Juliana C Ferreira; Juliana C O Ferreira; Katia R Silva; Karina L M Bastos; Katia Kozu; Lilian M Cristofani; Lucas V B Souza; Lucia M A Campos; Luiz Vicente R F Silva Filho; Marcelo T Sapienza; Marcos S Lima; Marlene P Garanito; Márcia F A Santos; Mayra B Dorna; Nadia E Aikawa; Nadia Litvinov; Neusa K Sakita; Paula V V Gaiolla; Paula Pasqualucci; Ricardo K Toma; Simone Correa-Silva; Sofia M Sieczkowska; Marta Imamura; Silvana Forsait; Vera A Santos; Yingying Zheng Journal: Clinics (Sao Paulo) Date: 2021-11-26 Impact factor: 2.898