SCOPE: In recent decades, the association among diet, gut microbiota, and the risk of colorectal cancer (CRC) has been established. Gut microbiota and associated metabolites, such as bile acids and butyrate, are now known to play a key role in CRC development. The aim of this study is to identify that the progression to CRC is influenced by cholic acid, sodium butyrate, a high-fat diet, or different dose of dihydromyricetin (DMY) interacted with gut microbiota. METHODS AND RESULTS: An AOM/DSS (azoxymethan/dextran sodium sulfate) model is established to study the gut microbiota compsition before and after tumor formation during colitis-induced tumorigenesis. All above dietary factors profoundly influence the composition of gut microbiota and host colonic tumorigenesis. In addition, mice with DMY-modified initial microbiota display different degrees of chemically induced tumorigenesis. Mechanism analysis reveals that gut microbiota-associated chloride channels participated in colon tumorigenesis. CONCLUSION: Gut microbiota changes occur in the hyperproliferative stage before tumor formation. Gut microbiota and host chloride channels, both of which are regulated by dietary factors, are associated with CRC development.
SCOPE: In recent decades, the association among diet, gut microbiota, and the risk of colorectal cancer (CRC) has been established. Gut microbiota and associated metabolites, such as bile acids and butyrate, are now known to play a key role in CRC development. The aim of this study is to identify that the progression to CRC is influenced by cholic acid, sodium butyrate, a high-fat diet, or different dose of dihydromyricetin (DMY) interacted with gut microbiota. METHODS AND RESULTS: An AOM/DSS (azoxymethan/dextran sodium sulfate) model is established to study the gut microbiota compsition before and after tumor formation during colitis-induced tumorigenesis. All above dietary factors profoundly influence the composition of gut microbiota and host colonic tumorigenesis. In addition, mice with DMY-modified initial microbiota display different degrees of chemically induced tumorigenesis. Mechanism analysis reveals that gut microbiota-associated chloride channels participated in colon tumorigenesis. CONCLUSION: Gut microbiota changes occur in the hyperproliferative stage before tumor formation. Gut microbiota and host chloride channels, both of which are regulated by dietary factors, are associated with CRC development.
Authors: Li Liu; Fred K Tabung; Xuehong Zhang; Jonathan A Nowak; Zhi Rong Qian; Tsuyoshi Hamada; Daniel Nevo; Susan Bullman; Kosuke Mima; Keisuke Kosumi; Annacarolina da Silva; Mingyang Song; Yin Cao; Tyler S Twombly; Yan Shi; Hongli Liu; Mancang Gu; Hideo Koh; Wanwan Li; Chunxia Du; Yang Chen; Chenxi Li; Wenbin Li; Raaj S Mehta; Kana Wu; Molin Wang; Aleksander D Kostic; Marios Giannakis; Wendy S Garrett; Curtis Hutthenhower; Andrew T Chan; Charles S Fuchs; Reiko Nishihara; Shuji Ogino; Edward L Giovannucci Journal: Clin Gastroenterol Hepatol Date: 2018-04-24 Impact factor: 11.382
Authors: Yang Yang; Yadan Liu; Juan Liu; Haizhen Wang; Yulong Guo; Min Du; Chunbo Cai; Yan Zhao; Chang Lu; Xiaohong Guo; Guoqing Cao; Zhibian Duan; Bugao Li; Pengfei Gao Journal: Front Vet Sci Date: 2021-07-15