Ningning Di1,2, Chenjun Yao3, Wenna Cheng4, Yan Ren2, Jianxun Qu5, Bin Wang6, Zhenwei Yao2. 1. Department of Radiology, Binzhou Medical University Hospital, Binzhou, China. 2. Department of Radiology, Huashan Hospital Fudan University, Shanghai, China. 3. Department of Neurosurgery, Huashan Hospital Fudan University, Shanghai, China. 4. Department of Pharmacy, Binzhou Medical University Affiliated Hospital, Binzhou, China. 5. GE Healthcare, Shanghai, China. 6. Department of Medical Imaging and Nuclear Medicine, Binzhou Medical University, Yantai, China.
Abstract
INTRODUCTION: To ascertain if the volume transfer constant (Ktrans ) derived from T1 dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) correlates with the immunohistological markers of angiogenesis in high-grade gliomas. METHODS: Fifty-one image-guided biopsy specimens in 34 patients with newly presenting high-grade gliomas (grade III = 16; grade IV = 18) underwent preoperative imaging (conventional imaging and T1 DCE-MRI). We correlated vascular endothelial growth factor (VEGF) expression and the microvessel density (MVD) of MRI-guided biopsy specimens with the corresponding DCE-derived Ktrans . Histological sections were stained with VEGF and CD34, and examined under light microscopy. These histological and molecular markers of angiogenesis were correlated with the Ktrans of the region of interest corresponding to the biopsy specimen. RESULTS: The Ktrans showed a significant positive correlation with VEGF expression (ρ = 0.582, P = 0.001) but not with MVD stained with CD34 antibody (ρ = 0.328, P = 0.072). CONCLUSION: The Ktrans derived from DCE-MRI can reflect the VEGF expression of high-grade gliomas but not the MVD.
INTRODUCTION: To ascertain if the volume transfer constant (Ktrans ) derived from T1 dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) correlates with the immunohistological markers of angiogenesis in high-grade gliomas. METHODS: Fifty-one image-guided biopsy specimens in 34 patients with newly presenting high-grade gliomas (grade III = 16; grade IV = 18) underwent preoperative imaging (conventional imaging and T1 DCE-MRI). We correlated vascular endothelial growth factor (VEGF) expression and the microvessel density (MVD) of MRI-guided biopsy specimens with the corresponding DCE-derived Ktrans . Histological sections were stained with VEGF and CD34, and examined under light microscopy. These histological and molecular markers of angiogenesis were correlated with the Ktrans of the region of interest corresponding to the biopsy specimen. RESULTS: The Ktrans showed a significant positive correlation with VEGF expression (ρ = 0.582, P = 0.001) but not with MVD stained with CD34 antibody (ρ = 0.328, P = 0.072). CONCLUSION: The Ktrans derived from DCE-MRI can reflect the VEGF expression of high-grade gliomas but not the MVD.
Authors: Hans Jonas Meyer; Leonard Leifels; Gordian Hamerla; Anne Kathrin Höhn; Alexey Surov Journal: Contrast Media Mol Imaging Date: 2019-01-02 Impact factor: 3.161
Authors: Jean-Philip Daniel Weber; Judith Eva Spiro; Matthias Scheffler; Jürgen Wolf; Lucia Nogova; Marc Tittgemeyer; David Maintz; Hendrik Laue; Thorsten Persigehl Journal: PLoS One Date: 2022-03-08 Impact factor: 3.240