Literature DB >> 29330808

Detection of Hypoxia and HIF in Paraffin-Embedded Tumor Tissues.

Fuming Li1,2, Kyoung Eun Lee1,2, M Celeste Simon3,4.   

Abstract

Hypoxia (insufficient O2 availability) is involved in various biological processes, such as tumorigenesis and inflammation. Hypoxia results in stabilization of hypoxia-inducible factors (HIFs) including HIF1α and HIF2α. Here we describe a protocol to detect mouse and human tissue hypoxia by using Hypoxyprobe and immunohistochemical staining for HIF1α and HIF2α.

Entities:  

Keywords:  HIF1α; HIF2α; Hypoxia; Hypoxyprobe; Immunohistochemistry

Mesh：

Substances：

Year:  2018        PMID： 29330808      PMCID： PMC6002766          DOI： 10.1007/978-1-4939-7665-2_24

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  6 in total

1.  Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia.

Authors:  Kyoung Eun Lee; Michelle Spata; Lauren J Bayne; Elizabeth L Buza; Amy C Durham; David Allman; Robert H Vonderheide; M Celeste Simon
Journal:  Cancer Discov       Date:  2015-12-29       Impact factor: 39.397

2.  Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.

Authors:  T S Karin Eisinger-Mathason; Minsi Zhang; Qiong Qiu; Nicolas Skuli; Michael S Nakazawa; Tatiana Karakasheva; Vera Mucaj; Jessica E S Shay; Lars Stangenberg; Navid Sadri; Ellen Puré; Sam S Yoon; David G Kirsch; M Celeste Simon
Journal:  Cancer Discov       Date:  2013-08-01       Impact factor: 39.397

Review 3.  Hypoxia-inducible factors: key regulators of myeloid cells during inflammation.

Authors:  Nan Lin; M Celeste Simon
Journal:  J Clin Invest       Date:  2016-09-06       Impact factor: 14.808

4.  SnapShot: Hypoxia-Inducible Factors.

Authors:  Kyoung Eun Lee; M Celeste Simon
Journal:  Cell       Date:  2015-11-19       Impact factor: 41.582

Review 5.  Oxygen availability and metabolic adaptations.

Authors:  Michael S Nakazawa; Brian Keith; M Celeste Simon
Journal:  Nat Rev Cancer       Date:  2016-09-23       Impact factor: 60.716

6.  HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma.

Authors:  John D Gordan; Priti Lal; Vijay R Dondeti; Richard Letrero; Krishna N Parekh; C Elisa Oquendo; Roger A Greenberg; Keith T Flaherty; W Kimryn Rathmell; Brian Keith; M Celeste Simon; Katherine L Nathanson
Journal:  Cancer Cell       Date:  2008-12-09       Impact factor: 31.743
  6 in total
  3 in total

1.  Comparative transcriptomic analysis of vascular endothelial cells after hypoxia/re-oxygenation induction based on microarray technology.

Authors:  Jia Xu; Jiu-Kun Jiang; Xiao-Lin Li; Xiao-Peng Yu; Ying-Ge Xu; Yuan-Qiang Lu
Journal:  J Zhejiang Univ Sci B       Date:  2020 Apr.       Impact factor: 3.066

2.  Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis.

Authors:  Suchitra Natarajan; Kaitlyn M Foreman; Michaela I Soriano; Ninna S Rossen; Hussein Shehade; Daniel R Fregoso; Joshua T Eggold; Venkatesh Krishnan; Oliver Dorigo; Adam J Krieg; Sarah C Heilshorn; Subarna Sinha; Katherine C Fuh; Erinn B Rankin
Journal:  Cancer Res       Date:  2019-03-12       Impact factor: 12.701

3.  Evaluating the Treatment Efficacy of Nano-Drug in a Lung Cancer Model Using Advanced Functional Magnetic Resonance Imaging.

Authors:  Cuiqing Huang; Jianye Liang; Mengjie Ma; Qingqing Cheng; Xi Xu; Dong Zhang; Changzheng Shi; Ning Shang; Zeyu Xiao; Liangping Luo
Journal:  Front Oncol       Date:  2020-09-29       Impact factor: 6.244
  3 in total

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