Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 An update on the role of nanovehicles in nose-to-brain drug delivery.

Literature DB >> 29330120

An update on the role of nanovehicles in nose-to-brain drug delivery.

Yunhai Feng¹, Haisheng He², Fengqian Li¹, Yi Lu², Jianping Qi², Wei Wu³.

Abstract

A quantitative analysis has cast doubt over the limited advantages provided by particles for nose-to-brain (NTB) drug delivery. Thus, it is imperative to identify the role of nanovehicles in NTB drug delivery. If nanocarriers are used merely as an option to improve various properties of the drugs or the formulations, it is difficult for them to outperform conventional formulations, such as solutions or gels. However, nanovehicles bring about special features, such as maintenance of the solubilized state of drugs, sustained or delayed release, and enhanced penetration because of surface modifications, all of which lead to enhanced NTB delivery efficiency.

Entities: Chemical

Mesh：

Substances：
Drug Carriers

Year: 2018 PMID： 29330120 DOI： 10.1016/j.drudis.2018.01.005

Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851

Keyword Cloud
Cited

18 in total

1. Superiority of TPGS-loaded micelles in the brain delivery of vinpocetine via administration of thermosensitive intranasal gel.

Authors: Tarek A Ahmed; Khalid M El-Say; Osama Aa Ahmed; Bader M Aljaeid
Journal: Int J Nanomedicine Date: 2019-07-23

10. Mixed Amphiphilic Polymeric Nanoparticles of Chitosan, Poly(vinyl alcohol) and Poly(methyl methacrylate) for Intranasal Drug Delivery: A Preliminary In Vivo Study.

Authors: Inbar Schlachet; Hen Moshe Halamish; Alejandro Sosnik
Journal: Molecules Date: 2020-09-30 Impact factor: 4.411

An update on the role of nanovehicles in nose-to-brain drug delivery.

1. Superiority of TPGS-loaded micelles in the brain delivery of vinpocetine via administration of thermosensitive intranasal gel.

2. Donepezil HCl Liposomes: Development, Characterization, Cytotoxicity, and Pharmacokinetic Study.

Review 3. Lipid-Based Nanocarriers via Nose-to-Brain Pathway for Central Nervous System Disorders.

4. Impact of particle size and pH on protein corona formation of solid lipid nanoparticles: A proof-of-concept study.

Review 5. New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan.

6. Formulation Strategies to Improve Nose-to-Brain Delivery of Donepezil.

7. RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery.

Review 8. Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting.

Review 9. Liposomal Formulations for Nose-to-Brain Delivery: Recent Advances and Future Perspectives.

10. Mixed Amphiphilic Polymeric Nanoparticles of Chitosan, Poly(vinyl alcohol) and Poly(methyl methacrylate) for Intranasal Drug Delivery: A Preliminary In Vivo Study.