Brian Pietrosimone1, Daniel Nissman2, Darin A Padua3, J Troy Blackburn3, Matthew S Harkey4, Robert A Creighton5, Ganesh M Kamath5, Kaitlin Healy5, Randy Schmitz6, Jeffrey B Driban4, Steve W Marshall7, Joanne M Jordan8, Jeffrey T Spang5. 1. Department of Exercise and Sport Science, 209 Fetzer Hall, University of North Carolina at Chapel Hill, Chapel Hill 27599, NC, United States; Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill 27519, NC, United States. Electronic address: brian@unc.edu. 2. Department of Radiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill 27599, NC, United States. 3. Department of Exercise and Sport Science, 209 Fetzer Hall, University of North Carolina at Chapel Hill, Chapel Hill 27599, NC, United States; Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill 27519, NC, United States. 4. Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Boston 02111, MA, United States. 5. Department of Orthopaedics, School of Medicine, University of North Carolina at Chapel Hill, 27599, NC, United States. 6. Department of Kinesiology, 1400 Spring Garden Street, University of North Carolina at Greensboro, Greensboro 27412, NC, United States. 7. Injury Prevention Research Center, CVS Plaza, Suite 500 CB# 7505, 137 E Franklin St, University of North Carolina at Chapel Hill, NC 27599, United States. 8. Thurston Arthritis Research Center, Thurston Building, University of North Carolina at Chapel Hill, 27599, United States.
Abstract
BACKGROUND: Lower proteoglycan density (PGD) of the articular cartilage may be an early marker of osteoarthritis following anterior cruciate ligament (ACL) reconstruction (ACL-R). The purpose this study was to determine associations between the Knee Injury and Osteoarthritis Outcomes Score (KOOS) and PGD of the articular cartilage in the femur and tibia 12-months following ACL-R. METHODS: We evaluated KOOS pain, symptoms, function in activities of daily living (ADL), function in sport and recreation (Sport), and quality of life (QOL), as well as PGD using T1rho magnetic resonance imaging in 18 individuals 12.50±0.70months (these are all mean±standard deviation) following unilateral ACL-R (10 females, eight males; 22.39±4.19years; Marx Score=10.93±3.33). Medial and lateral load-bearing portions of the femoral and tibial condyles were sectioned into three (anterior, central and posterior) regions of interest (ROIs). T1rho relaxation times in the ACL-R knee were normalized to the same regions of interest in the non-surgical knees. Alpha levels were set at P≤0.05. RESULTS: Worse KOOS outcomes were significantly associated with greater T1rho relaxation time ratios in the posterior-lateral femoral condyle [pain (r=-0.54), ADL (r=-0.56), Sport (r=-0.62) and QOL (r=-0.59)] central-lateral femoral condyle [Sport (r=-0.48) and QOL (r=-0.42)], and the anterior-medial femoral condyle [Sport (r=-0.46) and QOL (r=-0.40)]. There were no significant associations between the KOOS and T1rho outcomes for tibial ROI. CONCLUSIONS: Lower PGD of the femoral cartilage in the ACL-R knees was associated with worse patient-reported outcomes.
BACKGROUND: Lower proteoglycan density (PGD) of the articular cartilage may be an early marker of osteoarthritis following anterior cruciate ligament (ACL) reconstruction (ACL-R). The purpose this study was to determine associations between the Knee Injury and Osteoarthritis Outcomes Score (KOOS) and PGD of the articular cartilage in the femur and tibia 12-months following ACL-R. METHODS: We evaluated KOOS pain, symptoms, function in activities of daily living (ADL), function in sport and recreation (Sport), and quality of life (QOL), as well as PGD using T1rho magnetic resonance imaging in 18 individuals 12.50±0.70months (these are all mean±standard deviation) following unilateral ACL-R (10 females, eight males; 22.39±4.19years; Marx Score=10.93±3.33). Medial and lateral load-bearing portions of the femoral and tibial condyles were sectioned into three (anterior, central and posterior) regions of interest (ROIs). T1rho relaxation times in the ACL-R knee were normalized to the same regions of interest in the non-surgical knees. Alpha levels were set at P≤0.05. RESULTS: Worse KOOS outcomes were significantly associated with greater T1rho relaxation time ratios in the posterior-lateral femoral condyle [pain (r=-0.54), ADL (r=-0.56), Sport (r=-0.62) and QOL (r=-0.59)] central-lateral femoral condyle [Sport (r=-0.48) and QOL (r=-0.42)], and the anterior-medial femoral condyle [Sport (r=-0.46) and QOL (r=-0.40)]. There were no significant associations between the KOOS and T1rho outcomes for tibial ROI. CONCLUSIONS: Lower PGD of the femoral cartilage in the ACL-R knees was associated with worse patient-reported outcomes.
Authors: Matthew P Ithurburn; Andrew M Zbojniewicz; Staci Thomas; Kevin D Evans; Michael L Pennell; Robert A Magnussen; Mark V Paterno; Laura C Schmitt Journal: Knee Surg Sports Traumatol Arthrosc Date: 2018-11-16 Impact factor: 4.342
Authors: Alyssa Evans-Pickett; Caroline Lisee; W Zachary Horton; David Lalush; Daniel Nissman; J Troy Blackburn; Jeffrey T Spang; Brian Pietrosimone Journal: Med Sci Sports Exerc Date: 2022-06-11
Authors: Brian Pietrosimone; Matthew K Seeley; Christopher Johnston; Steven J Pfeiffer; Jeffery T Spang; J Troy Blackburn Journal: Med Sci Sports Exerc Date: 2019-02
Authors: Michelle C Boling; Matthew Dupell; Steven J Pfeiffer; Kyle Wallace; David Lalush; Jeffrey T Spang; Daniel Nissman; Brian Pietrosimone Journal: Arthritis Care Res (Hoboken) Date: 2022-04-13 Impact factor: 5.178
Authors: Steven J Pfeiffer; Jeffrey T Spang; Daniel Nissman; David Lalush; Kyle Wallace; Matthew S Harkey; Laura S Pietrosimone; Darin Padua; Troy Blackburn; Brian Pietrosimone Journal: Orthop J Sports Med Date: 2021-07-21