Literature DB >> 29327930

Synthesis of Cyclic Enones by Allyl-Palladium-Catalyzed α,β-Dehydrogenation.

David Huang1, Yizhou Zhao1, Timothy R Newhouse1.   

Abstract

The use of allyl-palladium catalysis for the one-step α,β-dehydrogenation of ketones via their zinc enolates is reported. The optimized protocol utilizes commercially available Zn(TMP)2 as base and diethyl allyl phosphate as oxidant. Notably, this transformation operates under salt-free conditions and tolerates a diverse scope of cycloalkanones.

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Year:  2018        PMID： 29327930      PMCID： PMC7913890          DOI： 10.1021/acs.orglett.7b03818

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


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