Literature DB >> 2932792

Influence of faeces on the activity of antimicrobial agents used for decontamination of the alimentary canal.

J J van Saene, H K van Saene, C P Stoutenbeek, C F Lerk.   

Abstract

The influence of faeces on the activity of 9 antibiotics currently used for selective decontamination of the digestive tract was studied. These in vitro findings showed that the antimicrobial activity is differently affected by the presence and concentration of faeces. Great differences in loss of activity were observed on different microorganisms. Decontaminating drugs which were found to be minimally inactivated in vitro by the presence of faeces are proven to be superior in clinical studies too.

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Year:  1985        PMID： 2932792

Source DB:  PubMed          Journal:  Scand J Infect Dis        ISSN： 0036-5548


  8 in total

Review 1.  Selective decontamination of the digestive tract in intensive care.

Authors:  S J Boom; G Ramsay
Journal:  Epidemiol Infect       Date:  1992-12       Impact factor: 2.451

Review 2.  Review of available trials of selective decontamination of the digestive tract (SDD).

Authors:  H K van Saene; C P Stoutenbeek; A A Gilbertson
Journal:  Infection       Date:  1990       Impact factor: 3.553

3.  Inappropriate dose of enteral antimicrobials promotes resistance.

Authors:  L Silvestri; C Negri; N Taylor; D F Zandstra; H K F van Saene
Journal:  J Clin Microbiol       Date:  2013-05       Impact factor: 5.948

4.  Enterobacteriaceae suppression by three different oral doses of polymyxin E in human volunteers.

Authors:  J J van Saene; H K van Saene; N J Tarko-Smit; G J Beukeveld
Journal:  Epidemiol Infect       Date:  1988-06       Impact factor: 2.451

Review 5.  Colonization resistance.

Authors:  E J Vollaard; H A Clasener
Journal:  Antimicrob Agents Chemother       Date:  1994-03       Impact factor: 5.191

6.  Mechanisms of failure to decontaminate the gut with polymixin E, gentamicin and amphotericin B in patients in intensive care.

Authors:  B Misset; M D Kitzis; G Conscience; F Goldstein; A Fourrier; J Carlet
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1994-02       Impact factor: 3.267

7.  Selective decontamination of the colon before elective colorectal surgery. West of Scotland Surgical Infection Study Group.

Authors:  E W Taylor; G Lindsay
Journal:  World J Surg       Date:  1994 Nov-Dec       Impact factor: 3.352

8.  Norfloxacin binds to human fecal material.

Authors:  C Edlund; L Lindqvist; C E Nord
Journal:  Antimicrob Agents Chemother       Date:  1988-12       Impact factor: 5.191
  8 in total

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