Maximilian S Holzmann1, Martin S Winkler1, Mike S Strunden2, Jakob R Izbicki3, Gerhard Schoen4, Gillis Greiwe1, Hans O Pinnschmidt4, Annika Poppe1, Bernd Saugel1, Guenter Daum5, Alwin E Goetz1, Kai Heckel1. 1. Department of Anesthesiology, Center of Anesthesiology & Intensive Care, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246, Hamburg, Germany. 2. Department of Anesthesiology & Intensive Care Asklepios Clinic Harburg, Eißendorfer Pferdeweg 52, 21052 Hamburg, Germany. 3. Department for General, Visceral & Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246, Hamburg, Germany. 4. Institute for Medical Biometry & Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246, Hamburg, Germany. 5. Clinic & Polyclinic for Vascular Medicine, University Heart Center, Martinistr 52, 20246, Hamburg, Germany.
Abstract
AIM: Sepsis is a serious complication following surgery and identification of patients at risk is of high importance. Syndecan-1 (sSDC1) levels are known to be elevated during sepsis. MATERIALS & METHODS: Fifty-five patients scheduled for major abdominal surgery were prospectively included and sSDC1 concentrations were measured during hospital stay. RESULTS: Patients with postoperative sepsis showed a continued increase of sSDC1 levels and exhibited higher median sSDC1 concentrations at day 1 compared with nonseptic patients 90.3 versus 16.5 ng/ml. A significant association of sSDC1 levels with the incidence of sepsis and death was demonstrated. CONCLUSION: This study identifies sSDC1 as potential biomarker for sepsis and survival after abdominal surgery.
AIM: Sepsis is a serious complication following surgery and identification of patients at risk is of high importance. Syndecan-1 (sSDC1) levels are known to be elevated during sepsis. MATERIALS & METHODS: Fifty-five patients scheduled for major abdominal surgery were prospectively included and sSDC1 concentrations were measured during hospital stay. RESULTS:Patients with postoperative sepsis showed a continued increase of sSDC1 levels and exhibited higher median sSDC1 concentrations at day 1 compared with nonseptic patients 90.3 versus 16.5 ng/ml. A significant association of sSDC1 levels with the incidence of sepsis and death was demonstrated. CONCLUSION: This study identifies sSDC1 as potential biomarker for sepsis and survival after abdominal surgery.
Authors: Hendrik Drinhaus; Daniel C Schroeder; Nicolas Hunzelmann; Holger Herff; Thorsten Annecke; Bernd W Böttiger; Wolfgang A Wetsch Journal: J Clin Med Date: 2022-09-30 Impact factor: 4.964
Authors: John W Keyloun; Tuan D Le; Anthony E Pusateri; Robert L Ball; Bonnie C Carney; Thomas Orfeo; Kathleen E Brummel-Ziedins; Maria C Bravo; Melissa M McLawhorn; Lauren T Moffatt; Jeffrey W Shupp Journal: Shock Date: 2021-08-01 Impact factor: 3.533