Literature DB >> 29326430

EMT in cancer.

Thomas Brabletz1, Raghu Kalluri2, M Angela Nieto3, Robert A Weinberg4.   

Abstract

Similar to embryonic development, changes in cell phenotypes defined as an epithelial to mesenchymal transition (EMT) have been shown to play a role in the tumorigenic process. Although the first description of EMT in cancer was in cell cultures, evidence for its role in vivo is now widely reported but also actively debated. Moreover, current research has exemplified just how complex this phenomenon is in cancer, leaving many exciting, open questions for researchers to answer in the future. With these points in mind, we asked four scientists for their opinions on the role of EMT in cancer and the challenges faced by scientists working in this fast-moving field.

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Year:  2018        PMID： 29326430     DOI： 10.1038/nrc.2017.118

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  60 in total

Review 1.  Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.

Authors:  Jing Yang; Robert A Weinberg
Journal:  Dev Cell       Date:  2008-06       Impact factor: 12.270

Review 2.  Human correlates of provocative questions in pancreatic pathology.

Authors:  Oliver G McDonald; Anirban Maitra; Ralph H Hruban
Journal:  Adv Anat Pathol       Date:  2012-11       Impact factor: 3.875

3.  Collective invasion in breast cancer requires a conserved basal epithelial program.

Authors:  Kevin J Cheung; Edward Gabrielson; Zena Werb; Andrew J Ewald
Journal:  Cell       Date:  2013-12-12       Impact factor: 41.582

Review 4.  Oncogenic roles of EMT-inducing transcription factors.

Authors:  Alain Puisieux; Thomas Brabletz; Julie Caramel
Journal:  Nat Cell Biol       Date:  2014-06       Impact factor: 28.824

5.  Breast tumor cell-specific knockout of Twist1 inhibits cancer cell plasticity, dissemination, and lung metastasis in mice.

Authors:  Yixiang Xu; Dong-Kee Lee; Zhen Feng; Yan Xu; Wen Bu; Yi Li; Lan Liao; Jianming Xu
Journal:  Proc Natl Acad Sci U S A       Date:  2017-10-09       Impact factor: 11.205

Review 6.  TGF-beta-induced epithelial to mesenchymal transition.

Authors:  Jian Xu; Samy Lamouille; Rik Derynck
Journal:  Cell Res       Date:  2009-02       Impact factor: 25.617

7.  Real-time imaging of the epithelial-mesenchymal transition using microRNA-200a sequence-based molecular beacon-conjugated magnetic nanoparticles.

Authors:  YoonSeok Choi; Hoe Suk Kim; Jisu Woo; Eun Hye Hwang; Kyoung-Won Cho; Soonhag Kim; Woo Kyung Moon
Journal:  PLoS One       Date:  2014-07-21       Impact factor: 3.240

8.  Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2.

Authors:  Rumela Chakrabarti; Julie Hwang; Mario Andres Blanco; Yong Wei; Martin Lukačišin; Rose-Anne Romano; Kirsten Smalley; Song Liu; Qifeng Yang; Toni Ibrahim; Laura Mercatali; Dino Amadori; Bruce G Haffty; Satrajit Sinha; Yibin Kang
Journal:  Nat Cell Biol       Date:  2012-10-21       Impact factor: 28.824

9.  Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.

Authors:  Xiaofeng Zheng; Julienne L Carstens; Jiha Kim; Matthew Scheible; Judith Kaye; Hikaru Sugimoto; Chia-Chin Wu; Valerie S LeBleu; Raghu Kalluri
Journal:  Nature       Date:  2015-11-11       Impact factor: 49.962

10.  Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance.

Authors:  Kari R Fischer; Anna Durrans; Sharrell Lee; Jianting Sheng; Fuhai Li; Stephen T C Wong; Hyejin Choi; Tina El Rayes; Seongho Ryu; Juliane Troeger; Robert F Schwabe; Linda T Vahdat; Nasser K Altorki; Vivek Mittal; Dingcheng Gao
Journal:  Nature       Date:  2015-11-11       Impact factor: 49.962
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  576 in total

1.  Landscape analysis of adjacent gene rearrangements reveals BCL2L14-ETV6 gene fusions in more aggressive triple-negative breast cancer.

Authors:  Sanghoon Lee; Yiheng Hu; Suet Kee Loo; Ying Tan; Rohit Bhargava; Michael T Lewis; Xiao-Song Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2020-04-22       Impact factor: 11.205

Review 2.  TGFβ biology in cancer progression and immunotherapy.

Authors:  Rik Derynck; Shannon J Turley; Rosemary J Akhurst
Journal:  Nat Rev Clin Oncol       Date:  2020-07-24       Impact factor: 66.675

3.  Grainyhead-like-2 confers NK-sensitivity through interactions with epigenetic modifiers.

Authors:  Ian MacFawn; Hannah Wilson; Luke A Selth; Ian Leighton; Ilya Serebriiskii; R Christopher Bleackley; Osama Elzamzamy; Joshua Farris; Phillip M Pifer; Jennifer Richer; Steven M Frisch
Journal:  Mol Immunol       Date:  2018-11-30       Impact factor: 4.407

4.  Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail/Slug protein translation.

Authors:  Wen-Die Wang; Yue Shang; Yi Li; Shu-Zhen Chen
Journal:  Acta Pharmacol Sin       Date:  2019-06-24       Impact factor: 6.150

5.  Systems-level Analysis Reveals Multiple Modulators of Epithelial-mesenchymal Transition and Identifies DNAJB4 and CD81 as Novel Metastasis Inducers in Breast Cancer.

Authors:  Zeynep Cansu Uretmen Kagiali; Erdem Sanal; Özge Karayel; Ayse Nur Polat; Özge Saatci; Pelin Gülizar Ersan; Kathrin Trappe; Bernhard Y Renard; Tamer T Önder; Nurcan Tuncbag; Özgür Şahin; Nurhan Ozlu
Journal:  Mol Cell Proteomics       Date:  2019-06-20       Impact factor: 5.911

Review 6.  Emerging Biomimetic Materials for Studying Tumor and Immune Cell Behavior.

Authors:  Logan A Northcutt; Alejandra Suarez-Arnedo; Marjan Rafat
Journal:  Ann Biomed Eng       Date:  2019-10-15       Impact factor: 3.934

Review 7.  Novel approaches to target the microenvironment of bone metastasis.

Authors:  Lorenz C Hofbauer; Aline Bozec; Martina Rauner; Franz Jakob; Sven Perner; Klaus Pantel
Journal:  Nat Rev Clin Oncol       Date:  2021-04-19       Impact factor: 66.675

8.  HOXB5 promotes malignant progression in pancreatic cancer via the miR-6732 pathway.

Authors:  Zhi-Xi Li; Gang Wu; Wen-Jun Jiang; Jie Li; You-Yu Wang; Xue-Ming Ju; Yan-Tao Yin
Journal:  Cell Cycle       Date:  2019-12-26       Impact factor: 4.534

9.  Long noncoding RNA lncARSR promotes epithelial ovarian cancer cell proliferation and invasion by association with HuR and miR-200 family.

Authors:  Chang Shu; Dongmei Yan; Yanxiang Mo; Jishuang Gu; Neelam Shah; Jin He
Journal:  Am J Cancer Res       Date:  2018-06-01       Impact factor: 6.166

Review 10.  Metal carcinogen exposure induces cancer stem cell-like property through epigenetic reprograming: A novel mechanism of metal carcinogenesis.

Authors:  Zhishan Wang; Chengfeng Yang
Journal:  Semin Cancer Biol       Date:  2019-01-11       Impact factor: 15.707
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