| Literature DB >> 29326057 |
Skyler J Mooney1, José N Nobrega2, Anthony J Levitt3, Kullervo Hynynen4.
Abstract
In many cases, hippocampal neurogenesis appears to be a hallmark of antidepressant treatments. One novel technique for inducing this type of neurogenesis is using focused ultrasound waves, in conjunction with circulating microbubbles, to open the blood-brain-barrier. The present experiment aimed to test whether this technique has antidepressant effects in a rodent model. Rats were subjected to 1, 2 or 3 weekly treatments of magnetic resonance-guided focused ultrasound in order to open the blood-brain-barrier in the hippocampal region. Before and after treatments, animals went through modified forced swim tests. 1 week after the final treatment, animals that received 2 weekly treatments showed antidepressant-like effects on behavioural measures in comparison to untreated controls. This was not the case for animals that received 1 or 3 weekly treatments. Effects had disappeared by 5 weeks following the first ultrasound treatment. These results suggest that focused ultrasound may be used for inducing short-term antidepressant effects.Entities:
Keywords: Antidepressants; Blood-brain barrier; Focused ultrasound; Forced swim test; Neurogenesis
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Year: 2018 PMID： 29326057 PMCID： PMC6207941 DOI： 10.1016/j.bbr.2018.01.004
Source DB: PubMed Journal: Behav Brain Res ISSN： 0166-4328 Impact factor: 3.332