Anat Milman1, Antoine Andorin2, Jean-Baptiste Gourraud2, Pieter G Postema3, Frederic Sacher4, Philippe Mabo5, Sung-Hwan Kim6, Jimmy J M Juang7, Shingo Maeda8, Yoshihide Takahashi8, Tsukasa Kamakura9, Takeshi Aiba9, Giulio Conte10, Georgia Sarquella-Brugada11, Eran Leshem12, Michael Rahkovich13, Aviram Hochstadt14, Yuka Mizusawa3, Elena Arbelo15, Zhengrong Huang16, Isabelle Denjoy17, Carla Giustetto18, Yanushi D Wijeyeratne19, Carlo Napolitano20, Yoav Michowitz1, Ramon Brugada21, Ruben Casado-Arroyo22, Jean Champagne23, Leonardo Calo24, Jacob Tfelt-Hansen25, Silvia G Priori20, Masahiko Takagi26, Christian Veltmann27, Pietro Delise28, Domenico Corrado29, Elijah R Behr19, Fiorenzo Gaita18, Gan-Xin Yan30, Josep Brugada15, Antoine Leenhardt17, Arthur A M Wilde3, Pedro Brugada10, Kengo F Kusano9, Kenzo Hirao8, Gi-Byoung Nam31, Vincent Probst2, Bernard Belhassen32. 1. Department of Cardiology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 2. L'institut du Thorax, Service de Cardiologie, CHU de Nantes, Nantes, France. 3. Heart Centre AMC, Department of Clinical and Experimental Cardiology, University of Amsterdam, Amsterdam, The Netherlands. 4. Hôpital Cardiologique du Haut-Lévêque & Université Bordeaux, LIRYC Institute, Bordeaux, France. 5. Cardiology and Vascular Disease Division, Rennes University Health Centre, Rennes, France. 6. Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. 7. Cardiovascular Center and Division of Cardiology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. 8. Heart Rhythm Center, Tokyo Medical and Dental University, Tokyo, Japan. 9. Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan. 10. Heart Rhythm Management Centre, UZ-VUB, Brussels, Belgium. 11. Pediatric Arrhythmias, Electrophysiology and Sudden Death Unit, Cardiology, Department Hospital Sant Joan de Déu Barcelona, Universitat de Barcelona, Barcelona, Spain. 12. Department of Cardiology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Beth Israel Deaconess Medical Center, Boston, Massachusetts. 13. Department of Cardiology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Arrhythmia Services, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. 14. Department of Internal Medicine J, Tel Aviv Medical Center, Tel Aviv, Israel. 15. Cardiology Department, Cardiovascular Institute, Hospital Clinic and IDIBAPS, Barcelona, Spain. 16. Department of Cardiology, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China. 17. Service de Cardiologie et CNMR Maladies Cardiaques Héréditaires Rares, Hôpital Bichat, Université Paris Diderot, Sorbonne, Paris, France. 18. Division of Cardiology, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Torino, Torino, Italy. 19. Cardiovascular Sciences Research Center, St. George's University of London and Cardiology Clinical Academic Group, St. George's University Hospitals NHS Foundation Trust, London, United Kingdom. 20. Molecular Cardiology, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy. 21. Cardiovascular Genetics Center, Institut d'Investigació Biomèdica Girona-IdIBGi, Salt, Spain. 22. Department of Cardiology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium. 23. Quebec Heart and Lung Institute, Quebec City, Quebec, Canada. 24. Division of Cardiology, Policlinico Casilino, Rome, Italy. 25. Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Denmark; Department of Medicine and Surgery, University of Copenhagen, Copenhagen, Denmark. 26. Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan. 27. Division of Rhythmology and Electrophysiology, Department of Cardiology, Hannover Medical School, Hannover, Germany. 28. Division of Cardiology, Hospital of Peschiera del Garda, Veneto, Italy. 29. Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy. 30. Lankenau Medical Center, Wynnewood, Pennsylvania. 31. Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 32. Department of Cardiology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: bblhass@gmail.com.
Abstract
BACKGROUND: Detailed information on the profile of patients with Brugada syndrome (BrS) presenting their first arrhythmic event (AE) after prophylactic implantation of an implantable cardioverter-defibrillator (ICD) is limited. OBJECTIVES: The objectives of this study were (1) to compare clinical, electrocardiographic, electrophysiologic, and genetic profiles of patients who exhibited their first documented AE as aborted cardiac arrest (group A) with profiles of those in whom the AE was documented after prophylactic ICD implantation (group B) and (2) to characterize group B patients' profile using the class II indications for ICD implantation established by HRS/EHRA/APHRS expert consensus statement in 2013. METHODS: A survey of 23 centers from 10 Western and 4 Asian countries enabled data collection of 678 patients with BrS who exhibited their AE (group A, n = 426; group B, n = 252). RESULTS: The first AE occurred in group B patients 6.7 years later than in group A (mean age 46.1 ± 13.3 years vs 39.4 ± 15.1 years; P < .001). Group B patients had a higher incidence of family history of sudden cardiac death and SCN5A mutations. Of the 252 group B patients, 189 (75%) complied with the HRS/EHRA/APHRS indications whereas the remaining 63 (25%) did not. CONCLUSION: Patients with BrS with the first AE documented after prophylactic ICD implantation exhibited their AE at a later age with a higher incidence of positive family history of sudden cardiac death and SCN5A mutations as compared with those presenting with aborted cardiac arrest. Only 75% of patients who exhibited an AE after receiving a prophylactic ICD complied with the 2013 class II indications, suggesting that efforts are still required for improving risk stratification.
BACKGROUND: Detailed information on the profile of patients with Brugada syndrome (BrS) presenting their first arrhythmic event (AE) after prophylactic implantation of an implantable cardioverter-defibrillator (ICD) is limited. OBJECTIVES: The objectives of this study were (1) to compare clinical, electrocardiographic, electrophysiologic, and genetic profiles of patients who exhibited their first documented AE as aborted cardiac arrest (group A) with profiles of those in whom the AE was documented after prophylactic ICD implantation (group B) and (2) to characterize group B patients' profile using the class II indications for ICD implantation established by HRS/EHRA/APHRS expert consensus statement in 2013. METHODS: A survey of 23 centers from 10 Western and 4 Asian countries enabled data collection of 678 patients with BrS who exhibited their AE (group A, n = 426; group B, n = 252). RESULTS: The first AE occurred in group B patients 6.7 years later than in group A (mean age 46.1 ± 13.3 years vs 39.4 ± 15.1 years; P < .001). Group B patients had a higher incidence of family history of sudden cardiac death and SCN5A mutations. Of the 252 group B patients, 189 (75%) complied with the HRS/EHRA/APHRS indications whereas the remaining 63 (25%) did not. CONCLUSION:Patients with BrS with the first AE documented after prophylactic ICD implantation exhibited their AE at a later age with a higher incidence of positive family history of sudden cardiac death and SCN5A mutations as compared with those presenting with aborted cardiac arrest. Only 75% of patients who exhibited an AE after receiving a prophylactic ICD complied with the 2013 class II indications, suggesting that efforts are still required for improving risk stratification.
Authors: Arthur A M Wilde; Christopher Semsarian; Manlio F Márquez; Alireza Sepehri Shamloo; Michael J Ackerman; Euan A Ashley; Back Sternick Eduardo; Héctor Barajas-Martinez; Elijah R Behr; Connie R Bezzina; Jeroen Breckpot; Philippe Charron; Priya Chockalingam; Lia Crotti; Michael H Gollob; Steven Lubitz; Naomasa Makita; Seiko Ohno; Martín Ortiz-Genga; Luciana Sacilotto; Eric Schulze-Bahr; Wataru Shimizu; Nona Sotoodehnia; Rafik Tadros; James S Ware; David S Winlaw; Elizabeth S Kaufman; Takeshi Aiba; Andreas Bollmann; Jong-Il Choi; Aarti Dalal; Francisco Darrieux; John Giudicessi; Mariana Guerchicoff; Kui Hong; Andrew D Krahn; Ciorsti Mac Intyre; Judith A Mackall; Lluís Mont; Carlo Napolitano; Pablo Ochoa Juan; Petr Peichl; Alexandre C Pereira; Peter J Schwartz; Jon Skinner; Christoph Stellbrink; Jacob Tfelt-Hansen; Thomas Deneke Journal: J Arrhythm Date: 2022-05-31
Authors: Arthur A M Wilde; Christopher Semsarian; Manlio F Márquez; Alireza Sepehri Shamloo; Michael J Ackerman; Euan A Ashley; Eduardo Back Sternick; Héctor Barajas-Martinez; Elijah R Behr; Connie R Bezzina; Jeroen Breckpot; Philippe Charron; Priya Chockalingam; Lia Crotti; Michael H Gollob; Steven Lubitz; Naomasa Makita; Seiko Ohno; Martín Ortiz-Genga; Luciana Sacilotto; Eric Schulze-Bahr; Wataru Shimizu; Nona Sotoodehnia; Rafik Tadros; James S Ware; David S Winlaw; Elizabeth S Kaufman; Takeshi Aiba; Andreas Bollmann; Jong Il Choi; Aarti Dalal; Francisco Darrieux; John Giudicessi; Mariana Guerchicoff; Kui Hong; Andrew D Krahn; Ciorsti MacIntyre; Judith A Mackall; Lluís Mont; Carlo Napolitano; Juan Pablo Ochoa; Petr Peichl; Alexandre C Pereira; Peter J Schwartz; Jon Skinner; Christoph Stellbrink; Jacob Tfelt-Hansen; Thomas Deneke Journal: Europace Date: 2022-09-01 Impact factor: 5.486
Authors: Dimitrios Asvestas; Gary Tse; Adrian Baranchuk; George Bazoukis; Tong Liu; Athanasios Saplaouras; Panagiotis Korantzopoulos; Christina Goga; Michael Efremidis; Antonios Sideris; Konstantinos P Letsas Journal: Int J Cardiol Heart Vasc Date: 2018-03-08