Anastasios Raptis1, Michalis Xenos1,2, George Kouvelos3, Athanasios Giannoukas1,3, Miltiadis Matsagkas1,3. 1. Laboratory for Vascular Simulations, Institute of Vascular Diseases, Ioannina, Greece. 2. Department of Mathematics, University of Ioannina, Ioannina, Greece. 3. Department of Vascular Surgery, Faculty of Medicine, University of Thessaly, Larissa, Greece.
Abstract
OBJECTIVES: The objective of this study is to analyse the flow conditions in the AFX and Nellix endografts (EGs) accounting for their postimplantation configuration in patients with an endovascular aneurysm repair-treated abdominal aortic aneurysm. METHODS: We reconstructed post-endovascular aneurysm repair computed tomography scans of patients treated with an AFX or Nellix EG creating post-implantation EG models. We examined 16 patients, 8 in each group. The blood flow properties were obtained by computational fluid dynamics simulations and were subsequently compared with physiological infrarenal blood flow properties measured in 5 healthy subjects. Specifically, pressure drop, maximum velocity and wall shear stress were measured at peak systole and mean helicity at mid-diastole. RESULTS: Our statistical analyses showed that the haemodynamic properties in both control regions did not vary statistically after the implantation of either the AFX or the Nellix EG, except for helicity that was significantly lower in the abdominal part of the Nellix EG compared with the expected physiological measurement. Regardless of the overall blood flow restoration, it is important to note that low pressure drop was detected along the limbs of the AFX and suppressed blood helical motion was detected at the entrance of the Nellix device. CONCLUSIONS: It is observed from the results that the AFX EG has achieved absolute restoration of blood flow after endovascular aneurysm repair, although the development of secondary flow in the upper part of the EG and the low pressure drop in its limbs should be acknowledged. The Nellix EG also seems to be haemodynamically efficient. However, the suppression of helical flow before blood enters the device might raise concerns about its clinical application.
OBJECTIVES: The objective of this study is to analyse the flow conditions in the AFX and Nellix endografts (EGs) accounting for their postimplantation configuration in patients with an endovascular aneurysm repair-treated abdominal aortic aneurysm. METHODS: We reconstructed post-endovascular aneurysm repair computed tomography scans of patients treated with an AFX or Nellix EG creating post-implantation EG models. We examined 16 patients, 8 in each group. The blood flow properties were obtained by computational fluid dynamics simulations and were subsequently compared with physiological infrarenal blood flow properties measured in 5 healthy subjects. Specifically, pressure drop, maximum velocity and wall shear stress were measured at peak systole and mean helicity at mid-diastole. RESULTS: Our statistical analyses showed that the haemodynamic properties in both control regions did not vary statistically after the implantation of either the AFX or the Nellix EG, except for helicity that was significantly lower in the abdominal part of the Nellix EG compared with the expected physiological measurement. Regardless of the overall blood flow restoration, it is important to note that low pressure drop was detected along the limbs of the AFX and suppressed blood helical motion was detected at the entrance of the Nellix device. CONCLUSIONS: It is observed from the results that the AFX EG has achieved absolute restoration of blood flow after endovascular aneurysm repair, although the development of secondary flow in the upper part of the EG and the low pressure drop in its limbs should be acknowledged. The Nellix EG also seems to be haemodynamically efficient. However, the suppression of helical flow before blood enters the device might raise concerns about its clinical application.