Peter M Spieth1, Haibo Zhang2,3. 1. Department of Anesthesiology and Critical Care Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 2. Keenan Research Center for Biomedical Sciences, St. Michael's Hospital. 3. Interdepartmental Division of Critical Care Medicine, Departments of Anesthesia and Physiology, University of Toronto, Toronto, Ontario, Canada.
Abstract
PURPOSE OF REVIEW: The aim of the present review was to concisely summarize recent studies and current knowledge about effects of red blood cell storage injury in trauma patients. RECENT FINDINGS: Despite a pathophysiological rationale for older packed red blood cells (PRBCs) being associated with adverse events in the host organism, recent large clinical trials failed to show negative effects of transfusion with older PRBCs on clinically relevant outcomes in mixed patient population. However, there is a lack of well-designed randomized controlled trials focusing on the effects of storage lesion of PRBCs in trauma patients. SUMMARY: In the absence of specific evidence for trauma patients, we recommend to continue with a conservative transfusion regime and standard of care blood banking practice of using older PRBCs first.
PURPOSE OF REVIEW: The aim of the present review was to concisely summarize recent studies and current knowledge about effects of red blood cell storage injury in traumapatients. RECENT FINDINGS: Despite a pathophysiological rationale for older packed red blood cells (PRBCs) being associated with adverse events in the host organism, recent large clinical trials failed to show negative effects of transfusion with older PRBCs on clinically relevant outcomes in mixed patient population. However, there is a lack of well-designed randomized controlled trials focusing on the effects of storage lesion of PRBCs in traumapatients. SUMMARY: In the absence of specific evidence for traumapatients, we recommend to continue with a conservative transfusion regime and standard of care blood banking practice of using older PRBCs first.
Authors: Olga Mykhailova; Carly Olafson; Tracey R Turner; Angelo DʼAlessandro; Jason P Acker Journal: Transfusion Date: 2020-08-19 Impact factor: 3.157
Authors: Mathijs R Wirtz; Jordy Jurgens; Coert J Zuurbier; Joris J T H Roelofs; Philip C Spinella; Jennifer A Muszynski; J Carel Goslings; Nicole P Juffermans Journal: Transfusion Date: 2018-11-21 Impact factor: 3.157