| Literature DB >> 29323873 |
Ryu J Iwatate, Mako Kamiya1, Keitaro Umezawa, Hiroki Kashima, Mamiko Nakadate, Ryosuke Kojima, Yasuteru Urano2.
Abstract
We designed and synthesized an activatable near-infrared (NIR) fluorescent probe for γ-glutamyltransferase, based on an asymmetric silicon rhodamine scaffold with an optimized equilibrium of intramolecular spirocyclization. The synthesized probe exhibits dramatic NIR fluorescence activation and, in combination with previously reported probes, enables discrimination of tumors with different enzymatic profiles.Entities:
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Year: 2018 PMID: 29323873 DOI: 10.1021/acs.bioconjchem.7b00776
Source DB: PubMed Journal: Bioconjug Chem ISSN: 1043-1802 Impact factor: 4.774