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Literature DB >> 29323278

Structural biology of Zika virus and other flaviviruses.

S Saif Hasan¹, Madhumati Sevvana¹, Richard J Kuhn¹, Michael G Rossmann².

Abstract

Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) and Japanese encephalitis (JEV) viruses. ZIKV infections have been linked to fetal microcephaly and the paralytic Guillain-Barré syndrome. This review provides a comparative structural analysis of the assembly, maturation and host-cell entry of ZIKV with other flaviviruses, especially DENV. We also discuss the mechanisms of neutralization by antibodies.

Entities: Disease Species

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Year: 2018 PMID： 29323278 DOI： 10.1038/s41594-017-0010-8

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

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Cited

59 in total

1. Characterization of two engineered dimeric Zika virus envelope proteins as immunogens for neutralizing antibody selection and vaccine design.

Authors: Chunpeng Yang; Fang Zeng; Xinyu Gao; Shaojuan Zhao; Xuan Li; Sheng Liu; Na Li; Chenglin Deng; Bo Zhang; Rui Gong
Journal: J Biol Chem Date: 2019-05-28 Impact factor: 5.157

2. Refinement and Analysis of the Mature Zika Virus Cryo-EM Structure at 3.1 Å Resolution.

Authors: Madhumati Sevvana; Feng Long; Andrew S Miller; Thomas Klose; Geeta Buda; Lei Sun; Richard J Kuhn; Michael G Rossmann
Journal: Structure Date: 2018-06-26 Impact factor: 5.006

3. Flaviviruses have imperfect icosahedral symmetry.

Authors: Matthew D Therkelsen; Thomas Klose; Frank Vago; Wen Jiang; Michael G Rossmann; Richard J Kuhn
Journal: Proc Natl Acad Sci U S A Date: 2018-10-22 Impact factor: 11.205

4. Molecular Basis of a Protective/Neutralizing Monoclonal Antibody Targeting Envelope Proteins of both Tick-Borne Encephalitis Virus and Louping Ill Virus.

Authors: Xu Yang; Jianxun Qi; Ruchao Peng; Lianpan Dai; Ernest A Gould; George F Gao; Po Tien
Journal: J Virol Date: 2019-04-03 Impact factor: 5.103

Structural biology of Zika virus and other flaviviruses.

1. Characterization of two engineered dimeric Zika virus envelope proteins as immunogens for neutralizing antibody selection and vaccine design.

2. Refinement and Analysis of the Mature Zika Virus Cryo-EM Structure at 3.1 Å Resolution.

3. Flaviviruses have imperfect icosahedral symmetry.

4. Molecular Basis of a Protective/Neutralizing Monoclonal Antibody Targeting Envelope Proteins of both Tick-Borne Encephalitis Virus and Louping Ill Virus.

5. Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease.

Review 6. Subdominance in Antibody Responses: Implications for Vaccine Development.

Review 7. Mapping the diverse structural landscape of the flavivirus antibody repertoire.

8. Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity.

9. Disulfide Reduction Allosterically Destabilizes the β-Ladder Subdomain Assembly within the NS1 Dimer of ZIKV.

10. Zika virus pathogenesis and current therapeutic advances.