Katia Collomp1,2,3, Corinne Buisson4, Nicolas Gravisse5,6, Soraya Belgherbi7, Zakaria Labsy5,6, Manh-Cuong Do5,6, Olivier Gagey5,6, Sophie Dufay8, Nancy Vibarel-Rebot5,6, Michel Audran4. 1. CIAMS, Univ. Paris-Sud, Université Paris-Saclay, Orsay, France. katia.collomp@univ-orleans.fr. 2. CIAMS, Université Orléans, Orléans, France. katia.collomp@univ-orleans.fr. 3. Département des Analyses, AFLD, Chatenay-Malabry, France. katia.collomp@univ-orleans.fr. 4. Département des Analyses, AFLD, Chatenay-Malabry, France. 5. CIAMS, Univ. Paris-Sud, Université Paris-Saclay, Orsay, France. 6. CIAMS, Université Orléans, Orléans, France. 7. Service de Médecine Préventive, Univ. Paris-Sud, Université Paris-Saclay, Orsay, France. 8. Laboratoire de Développement Analytique, AGEPS, Paris, France.
Abstract
BACKGROUND:Dehydroepiandrosterone (DHEA) figures on the World Anti-Doping Agency list of prohibited substances in sport because it is assumed that athletes expect a significant increase in testosterone through DHEA administration. The literature on the hormonal effects of DHEA intake nevertheless appears to be very scant in healthy young subjects, especially women. PURPOSE: We examined the effects of DHEA on adrenal and gonadal hormones, IGF1 and free T3 in healthy young male and female recreationally trained volunteers. METHODS: The study followed a double-blind, randomized-order crossover design. Lean healthy young men (n = 10) and women (n = 11), with all women using oral contraceptives, were treated daily with 100 mg of DHEA and placebo for 4 weeks. DHEA, DHEA-sulfate (DHEA-S), androstenedione, total testosterone (Tes), dihydrotestosterone (DHT), SHBG, estrone, cortisol, IGF1, and free T3 were measured before, in the middle and at the end of each treatment, as were blood glucose, liver transaminases and lipid status. RESULTS: We observed a significant increase in DHEA, DHEA-S, androstenedione, Tes, DHT, and estrone in both men and women in the middle and at the end of DHEA treatment, but the increase in Tes was more marked in women (p < 0.001) than men (p < 0.05). No changes were found in the other parameters, irrespective of gender. CONCLUSION: In young athletes, DHEA administration induces significant blood hormonal changes, some modulated by gender, which can be used as biomarkers of doping.
RCT Entities:
BACKGROUND:Dehydroepiandrosterone (DHEA) figures on the World Anti-Doping Agency list of prohibited substances in sport because it is assumed that athletes expect a significant increase in testosterone through DHEA administration. The literature on the hormonal effects of DHEA intake nevertheless appears to be very scant in healthy young subjects, especially women. PURPOSE: We examined the effects of DHEA on adrenal and gonadal hormones, IGF1 and free T3 in healthy young male and female recreationally trained volunteers. METHODS: The study followed a double-blind, randomized-order crossover design. Lean healthy young men (n = 10) and women (n = 11), with all women using oral contraceptives, were treated daily with 100 mg of DHEA and placebo for 4 weeks. DHEA, DHEA-sulfate (DHEA-S), androstenedione, total testosterone (Tes), dihydrotestosterone (DHT), SHBG, estrone, cortisol, IGF1, and free T3 were measured before, in the middle and at the end of each treatment, as were blood glucose, liver transaminases and lipid status. RESULTS: We observed a significant increase in DHEA, DHEA-S, androstenedione, Tes, DHT, and estrone in both men and women in the middle and at the end of DHEA treatment, but the increase in Tes was more marked in women (p < 0.001) than men (p < 0.05). No changes were found in the other parameters, irrespective of gender. CONCLUSION: In young athletes, DHEA administration induces significant blood hormonal changes, some modulated by gender, which can be used as biomarkers of doping.
Entities:
Keywords:
Androstenedione; DHEA administration; DHT; Testosterone; Young females; Young males
Authors: Sven Christian Voss; Neil Robinson; Mohammed Alsayrafi; Pitre C Bourdon; Yorck Olaf Schumacher; Martial Saugy; Sylvain Giraud Journal: Drug Test Anal Date: 2014-05-14 Impact factor: 3.345
Authors: K Sreekumaran Nair; Robert A Rizza; Peter O'Brien; Ketan Dhatariya; Kevin R Short; Ajay Nehra; Janet L Vittone; George G Klee; Ananda Basu; Rita Basu; Claudio Cobelli; Gianna Toffolo; Chiara Dalla Man; Donald J Tindall; L Joseph Melton; Glenn E Smith; Sundeep Khosla; Michael D Jensen Journal: N Engl J Med Date: 2006-10-19 Impact factor: 91.245