Vanessa Tardio1, Jean-Philippe Blais2,3, Anne-Sophie Julien4, Pierre Douville5, Stefane Lebel6, Laurent Biertho6, Simon Marceau6, Frédéric-Simon Hould6, Claudia Gagnon7,8,9. 1. Division of Endocrinology and Metabolism, McGill University Health Center, Montreal, Quebec, Canada. 2. Endocrinology and Nephrology Unit, CHU de Québec Research Centre, Quebec City, Quebec, Canada. 3. Department of Medicine, Université Laval, Quebec City, Quebec, Canada. 4. Clinical Research Platform, CHU de Québec Research Centre, Quebec City, Quebec, Canada. 5. Medical Biochemistry Service, Quebec Heart and Lung Institute, Quebec City, Quebec, Canada. 6. Department of Bariatric and General Surgery, Quebec Heart and Lung Institute, Quebec City, Quebec, Canada. 7. Endocrinology and Nephrology Unit, CHU de Québec Research Centre, Quebec City, Quebec, Canada. claudia.gagnon@crchudequebec.ulaval.ca. 8. Department of Medicine, Université Laval, Quebec City, Quebec, Canada. claudia.gagnon@crchudequebec.ulaval.ca. 9. Institute of Nutrition and Functional Foods, Université Laval, Quebec City, Quebec, Canada. claudia.gagnon@crchudequebec.ulaval.ca.
Abstract
BACKGROUND: Biliopancreatic diversion with duodenal switch (BPD-DS) decreases vitamin D and calcium absorption, which may result in secondary hyperparathyroidism. This study aimed at evaluating the prevalence of vitamin D deficiency and secondary hyperparathyroidism before and after BPD-DS. METHODS: A retrospective analysis of patients who had undergone BPD-DS at a tertiary bariatric center between 2003 and 2010 and for whom simultaneous measurements of serum 25-hydroxyvitamin D and parathyroid hormone were available within 5 years post-op was performed. The prevalence of vitamin D deficiency (< 20 ng/ml) and secondary hyperparathyroidism (> 65 pg/mL) at different time points was calculated. RESULTS: Included were 1436 patients (mean ± SD, age 42.7 ± 10.4 years; BMI 51.5 ± 8.6 kg/m2; 69.8% women). Prevalence of vitamin D deficiency decreased up to 6-12 months after surgery (from 35.8% at baseline down to 6-9%) then rose progressively, plateauing at 15.5% after 36 months. Prevalence of hyperparathyroidism was 28.5% before surgery and rose progressively after surgery, reaching 68.6% at 5 years. Mean serum corrected calcium increased from 0 to 6 months then decreased up to 36 months. Preoperatively, the prevalence of hypocalcemia was 7.3%. It increased after 12 months, attaining 26.9% at 48 months. CONCLUSIONS: Prevalence of vitamin D deficiency and secondary hyperparathyroidism is high before BPD-DS. Despite a low prevalence of vitamin D deficiency after surgery, prevalence of hyperparathyroidism increased steadily 1 year after surgery, preceded by a decrease in serum calcium. Factors explaining the high prevalence of secondary hyperparathyroidism after BPD-DS and its long-term impact on bone health should be addressed.
BACKGROUND: Biliopancreatic diversion with duodenal switch (BPD-DS) decreases vitamin D and calcium absorption, which may result in secondary hyperparathyroidism. This study aimed at evaluating the prevalence of vitamin Ddeficiency and secondary hyperparathyroidism before and after BPD-DS. METHODS: A retrospective analysis of patients who had undergone BPD-DS at a tertiary bariatric center between 2003 and 2010 and for whom simultaneous measurements of serum 25-hydroxyvitamin D and parathyroid hormone were available within 5 years post-op was performed. The prevalence of vitamin D deficiency (< 20 ng/ml) and secondary hyperparathyroidism (> 65 pg/mL) at different time points was calculated. RESULTS: Included were 1436 patients (mean ± SD, age 42.7 ± 10.4 years; BMI 51.5 ± 8.6 kg/m2; 69.8% women). Prevalence of vitamin D deficiency decreased up to 6-12 months after surgery (from 35.8% at baseline down to 6-9%) then rose progressively, plateauing at 15.5% after 36 months. Prevalence of hyperparathyroidism was 28.5% before surgery and rose progressively after surgery, reaching 68.6% at 5 years. Mean serum corrected calcium increased from 0 to 6 months then decreased up to 36 months. Preoperatively, the prevalence of hypocalcemia was 7.3%. It increased after 12 months, attaining 26.9% at 48 months. CONCLUSIONS: Prevalence of vitamin Ddeficiency and secondary hyperparathyroidism is high before BPD-DS. Despite a low prevalence of vitamin D deficiency after surgery, prevalence of hyperparathyroidism increased steadily 1 year after surgery, preceded by a decrease in serum calcium. Factors explaining the high prevalence of secondary hyperparathyroidism after BPD-DS and its long-term impact on bone health should be addressed.
Entities:
Keywords:
Biliopancreatic diversion; Obesity; Parathyroid hormone; Secondary hyperparathyroidism; Vitamin D
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