Adriana Bosco1, Régis Lopez1, Lucie Barateau1, Sofiene Chenini1, Carole Pesenti1, Jean-Louis Pépin1, Isabelle Jaussent1, Yves Dauvilliers2. 1. From Centre National de Référence Narcolepsie Hypersomnies (A.B., R.L., L.B., S.C., C.P., Y.D.), Unité des Troubles du Sommeil, Service de Neurologie, Hôpital Gui-de-Chauliac Montpellier; Inserm U1061 (R.L., L.B., I.J., Y.D.), Montpellier; Université de Montpellier (R.L., L.B., C.P., I.J., Y.D.); CHU de Grenoble (J.-L.P.); Inserm U1042 (J.-L.P.), Grenoble; and Université Grenoble Alpes (J.-L.P.), Grenoble, France. 2. From Centre National de Référence Narcolepsie Hypersomnies (A.B., R.L., L.B., S.C., C.P., Y.D.), Unité des Troubles du Sommeil, Service de Neurologie, Hôpital Gui-de-Chauliac Montpellier; Inserm U1061 (R.L., L.B., I.J., Y.D.), Montpellier; Université de Montpellier (R.L., L.B., C.P., I.J., Y.D.); CHU de Grenoble (J.-L.P.); Inserm U1042 (J.-L.P.), Grenoble; and Université Grenoble Alpes (J.-L.P.), Grenoble, France. y-dauvilliers@chu-montpellier.fr.
Abstract
OBJECTIVE: To assess the effect of psychostimulant treatments on the 24-hour blood pressure (BP) profile of patients with narcolepsy type 1 (NT1). METHODS: Heart rate (HR) and BP were monitored for 24 hours and morning endothelial function was evaluated in 160 consecutive patients with NT1: 68 untreated (41 male, median age 34.9 years), 54 treated (32 male, median age 40.9 years), and 38 evaluated twice (21 male, median age 32 years), before and during treatment. RESULTS: Patients treated for NT1 showed higher 24-hour, daytime, and nighttime diastolic BP and HR values compared with the untreated group. Similarly, HR as well as 24-hour and daytime systolic BP were increased during treatment in the group evaluated twice. The combination of stimulant and anticataplectic drugs showed a synergistic effect on BP, without differences among stimulant categories. Based on 24-hour BP monitoring, hypertension was diagnosed in 58% of treated patients and in 40.6% of untreated patients. After adjustments for age, sex, and body mass index, the percentage of REM sleep remained associated with 24-hour hypertension in untreated and treated patients. Endothelial function was comparable in treated and untreated patients. CONCLUSIONS: The finding that patients with NT1 treated with psychostimulants have higher diastolic BP and HR than untreated patients suggests an increased long-term risk of cardiovascular diseases that requires careful follow-up and specific management.
OBJECTIVE: To assess the effect of psychostimulant treatments on the 24-hour blood pressure (BP) profile of patients with narcolepsy type 1 (NT1). METHODS: Heart rate (HR) and BP were monitored for 24 hours and morning endothelial function was evaluated in 160 consecutive patients with NT1: 68 untreated (41 male, median age 34.9 years), 54 treated (32 male, median age 40.9 years), and 38 evaluated twice (21 male, median age 32 years), before and during treatment. RESULTS:Patients treated for NT1 showed higher 24-hour, daytime, and nighttime diastolic BP and HR values compared with the untreated group. Similarly, HR as well as 24-hour and daytime systolic BP were increased during treatment in the group evaluated twice. The combination of stimulant and anticataplectic drugs showed a synergistic effect on BP, without differences among stimulant categories. Based on 24-hour BP monitoring, hypertension was diagnosed in 58% of treated patients and in 40.6% of untreated patients. After adjustments for age, sex, and body mass index, the percentage of REM sleep remained associated with 24-hour hypertension in untreated and treated patients. Endothelial function was comparable in treated and untreated patients. CONCLUSIONS: The finding that patients with NT1 treated with psychostimulants have higher diastolic BP and HR than untreated patients suggests an increased long-term risk of cardiovascular diseases that requires careful follow-up and specific management.
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