| Literature DB >> 29320709 |
Mario R Fernandez1, John L Cleveland2.
Abstract
One strategy to improve the potency of adoptive T cell therapy is to augment the function and persistence of anti-tumor T cells. In this issue of Cell Metabolism, Chatterjee et al. (2018) demonstrate that intratumoral CD4+ T cell functions and memory can be improved by targeting a CD38-NAD+-Sirt1-Foxo1 metabolic circuit.Entities:
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Year: 2018 PMID： 29320709 DOI： 10.1016/j.cmet.2017.12.014
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287