Liang Jingshan1,2, Fang Shengyu1,2, Fan Xing1,2, Wang Zheng1,2, Zhang Chuanbao1,2, Qian Zenghui1,2, Liu Xing1,2, Sun Lihua1,2, Li Guanzhang1,2, Yang Fuqiang1,2, Jin Shuai1, Wang Yinyan3,4, Jiang Tao5,6,7. 1. Beijing Neurosurgical Institute, Capital Medical University, 6, Tiantanxili, 100050, Beijing, China. 2. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. 3. Beijing Neurosurgical Institute, Capital Medical University, 6, Tiantanxili, 100050, Beijing, China. tiantanyinyan@126.com. 4. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. tiantanyinyan@126.com. 5. Beijing Neurosurgical Institute, Capital Medical University, 6, Tiantanxili, 100050, Beijing, China. taojiang1964@163.com. 6. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. taojiang1964@163.com. 7. Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China. taojiang1964@163.com.
Abstract
PURPOSE: The hand knob area is the cortical representation of motor hand function. The current study aimed to investigate the effects of eloquent area gliomas on the morphometry of the hand motor cortex and preoperative hand motor function. METHODS: A retrospective study of 320 glioma patients was conducted. Seventy-eight patients with gliomas involving motor functional area were finally enrolled. Using axial T2-weight magnetic resonance images, the width and height of the hand knob were measured in both hemispheres, and differences were compared between the affected and unaffected hemispheres. Receiver operating characteristic (ROC) curve and logistic regression analysis were used to estimate the degree of correlation between distance measurements and motor impairment. RESULTS: The width and height of the hand knob in the affected and unaffected hemispheres were significantly different (p < 0.0001). The width, height and distance from the tumor to hand knob were reduced in the functionally impaired group compared to the unimpaired group (p = 0.0003, p < 0.0001, p = 0.0005, respectively). The three parameters were significantly correlated and remained significant in ROC and logistic regression analysis. The optimal cut-off value of width, height and distance for identifying preoperative hand muscle strength were 5.73 mm, 5.80 mm and 5.92 mm, respectively. CONCLUSION: The morphometry of the hand knob is often changed by the infiltration or extrusion of the tumors that were located in or near the hand knob. The width, height of hand knob and the distance from tumor to hand knob could serve as anatomic biomarkers related to preoperative neurological motor deficits.
PURPOSE: The hand knob area is the cortical representation of motor hand function. The current study aimed to investigate the effects of eloquent area gliomas on the morphometry of the hand motor cortex and preoperative hand motor function. METHODS: A retrospective study of 320 gliomapatients was conducted. Seventy-eight patients with gliomas involving motor functional area were finally enrolled. Using axial T2-weight magnetic resonance images, the width and height of the hand knob were measured in both hemispheres, and differences were compared between the affected and unaffected hemispheres. Receiver operating characteristic (ROC) curve and logistic regression analysis were used to estimate the degree of correlation between distance measurements and motor impairment. RESULTS: The width and height of the hand knob in the affected and unaffected hemispheres were significantly different (p < 0.0001). The width, height and distance from the tumor to hand knob were reduced in the functionally impaired group compared to the unimpaired group (p = 0.0003, p < 0.0001, p = 0.0005, respectively). The three parameters were significantly correlated and remained significant in ROC and logistic regression analysis. The optimal cut-off value of width, height and distance for identifying preoperative hand muscle strength were 5.73 mm, 5.80 mm and 5.92 mm, respectively. CONCLUSION: The morphometry of the hand knob is often changed by the infiltration or extrusion of the tumors that were located in or near the hand knob. The width, height of hand knob and the distance from tumor to hand knob could serve as anatomic biomarkers related to preoperative neurological motor deficits.
Entities:
Keywords:
Glioma; Hand knob region; Hand muscle strength
Authors: F Wu; H Zhao; Y Zhang; M Wang; C Liu; X Wang; Y Cheng; C Jin; J Yang; X Li Journal: AJNR Am J Neuroradiol Date: 2022-01-06 Impact factor: 3.825