| Literature DB >> 29317340 |
Kathryn Konicke1, Argelia López-Luna2, José Luis Muñoz-Carrillo3, Luis Steven Servín-González4, Armando Flores-de la Torre2, Edit Olasz1, Zelmira Lazarova1.
Abstract
Cutaneous squamous cell carcinoma (cSCC) is a keratinocyte-derived skin tumor. It is the second-most-common cancer affecting the Caucasian population and is responsible for >20% of all skin-cancer-related deaths. The estimated incidence of non-melanoma skin cancer in the USA is >1000000 cases per year, of which roughly 20-30% are squamous cell carcinoma. To better understand and treat this challenging cancer, current research focuses on development of novel strategies to improve the understanding of tumor biogenesis on an individual basis. microRNAs are becoming important biomarkers in the diagnosis, prognosis and treatment of cSCC. This review describes the current knowledge on miRNA expression in cSCC and its role as a biomarker for personalized medicine.Entities:
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Year: 2018 PMID： 29317340 DOI： 10.1016/j.drudis.2018.01.023
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851