Literature DB >> 29317218

DLX1, a binding protein of beta-catenin, promoted the growth and migration of prostate cancer cells.

Ming Liang1, Yan Sun2, Huai-Liang Yang3, Bin Zhang3, Ji Wen3, Ben-Kang Shi4.   

Abstract

Several studies have indicated the involvement of DLX1 in the progression of prostate cancer. However, the functions of DLX1 in the prostate cancer and the underlying molecular mechanism remains largely unknown. In this study, we have shown that DLX1 was up-regulated in the prostate clinical samples. DLX1 promoted the growth, migration and colony formation of prostate cancer cells by activating beta-catenin/TCF signaling. DLX1 interacted with beta-catenin and enhanced the interaction between beta-catenin and TCF4. Taken together, this study demonstrated that DLX1 exerted the oncogenic roles on the prostate cancer by activating beta-catenin/TCF signaling.
Copyright © 2018. Published by Elsevier Inc.

Entities:  

Keywords:  Beta-catenin/TCF signaling; Cell growth and migration; DLX1; Prostate cancer

Mesh：

Substances：

Year:  2018        PMID： 29317218     DOI： 10.1016/j.yexcr.2018.01.007

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  9 in total

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  9 in total

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