K Selthofer-Relatić1,2, R Radić3, A Stupin4, V Šišljagić5, I Bošnjak1, N Bulj6, R Selthofer3, D Delić Brkljačić6. 1. 1 Department for Cardiovascular Disease, Osijek University Hospital, Osijek, Croatia. 2. 2 Department for Internal Medicine, Faculty of Medicine, University of Osijek, Osijek, Croatia. 3. 3 Department for Anatomy and Neuroscience, Faculty of Medicine, University of Osijek, Osijek, Croatia. 4. 4 Department for Physiology and Immunology, Faculty of Medicine, University of Osijek, Croatia. 5. 5 Department for Surgery, Osijek University Hospital, Osijek, Croatia. 6. 6 Deparment for Internal Medicine, School of Medicine, University of Zagreb, Zagreb, Croatia.
Abstract
OBJECTIVE: Obesity-related atherosclerosis is a systemic disease with a background connected to multiple metabolic-neurohumoral pathways. The leptin/adiponectin ratio has been suggested as an atherosclerotic marker in obese patients. The aim of this study was to assess (1) the significance of the L/A ratio in overweight subjects, (2) the relation with anthropometric/metabolic parameters and (3) gender difference. METHOD: The study included 80 adult males and females, overweight, non-diabetic patients. Biochemical blood analysis and anthropometric and cardiovascular measurements were performed. Serum leptin levels were measured with a radioimmunoassay test and total adiponectin levels with enzyme-linked immunosorbent assay. Leptin/adiponectin ratios were calculated as ratios between total serum concentrations of leptin and adiponectin. RESULTS: Differences between leptin, adiponectin serum levels and leptin/adiponectin ratios are presented in overweight persons, where females have a significantly higher leptin/adiponectin ratio than men ( p < 0.001). In men, the leptin/adiponectin ratio showed a positive correlation with total cholesterol levels ( p = 0.011), low-density lipoprotein ( p = 0.013) and triglycerides ( p = 0.032). In females, the leptin/adiponectin ratio correlated with anthropometric parameters of visceral obesity: waist circumference ( p = 0.001) and waist-to-hip ratio ( p = 0.025). CONCLUSION: The leptin/adiponectin ratio could represent an atherosclerotic risk marker of the early stage of obesity. Gender plays a significant role in pathophysiological changes, with different clinical manifestations, where sex hormones have a crucial effect on neurohumoral adipose tissue activity.
OBJECTIVE:Obesity-related atherosclerosis is a systemic disease with a background connected to multiple metabolic-neurohumoral pathways. The leptin/adiponectin ratio has been suggested as an atherosclerotic marker in obesepatients. The aim of this study was to assess (1) the significance of the L/A ratio in overweight subjects, (2) the relation with anthropometric/metabolic parameters and (3) gender difference. METHOD: The study included 80 adult males and females, overweight, non-diabeticpatients. Biochemical blood analysis and anthropometric and cardiovascular measurements were performed. Serum leptin levels were measured with a radioimmunoassay test and total adiponectin levels with enzyme-linked immunosorbent assay. Leptin/adiponectin ratios were calculated as ratios between total serum concentrations of leptin and adiponectin. RESULTS: Differences between leptin, adiponectin serum levels and leptin/adiponectin ratios are presented in overweight persons, where females have a significantly higher leptin/adiponectin ratio than men ( p < 0.001). In men, the leptin/adiponectin ratio showed a positive correlation with total cholesterol levels ( p = 0.011), low-density lipoprotein ( p = 0.013) and triglycerides ( p = 0.032). In females, the leptin/adiponectin ratio correlated with anthropometric parameters of visceral obesity: waist circumference ( p = 0.001) and waist-to-hip ratio ( p = 0.025). CONCLUSION: The leptin/adiponectin ratio could represent an atherosclerotic risk marker of the early stage of obesity. Gender plays a significant role in pathophysiological changes, with different clinical manifestations, where sex hormones have a crucial effect on neurohumoral adipose tissue activity.
Authors: Nicole L Mihalopoulos; Jeffrey T Yap; Britney Beardmore; Richard Holubkov; M Nazeem Nanjee; John M Hoffman Journal: Obesity (Silver Spring) Date: 2020-03-13 Impact factor: 5.002
Authors: Paulina Zabielska; Sylwia Wieder-Huszla; Izabela Gutowska; Anna Lubkowska; Anna Knyszyńska; Anna Jurczak Journal: Int J Environ Res Public Health Date: 2019-05-30 Impact factor: 3.390