Deqiang Cheng1, Yinping Zhuang2, Qiqi Kou1, Min Zhang3, Yinghong Zhao3, Cuiping Han3, Jingjing Li3, Yong Wang3, Kai Xu3, Fei Mo3, Jiawei Zhang3. 1. School of Information and Control Engineering, China University of Mining and Technology, Xuzhou 221116, China. 2. School of Information and Control Engineering, China University of Mining and Technology, Xuzhou 221116, China; School of Medical Imaging, Xuzhou Medical University, 84West Huai-hai Road, Xuzhou 221004, China. Electronic address: 100002009029@xzhmu.edu.cn. 3. School of Medical Imaging, Xuzhou Medical University, 84West Huai-hai Road, Xuzhou 221004, China.
Abstract
BACKGROUND: This study was performed to determine the hemodynamic changes of Budd-Chiari syndrome when the inferior vena vein membrane is developing. METHODS: A patient-specific Budd-Chiari syndrome vascular model was reconstructed based on magnetic resonance images using Mimics software and different degrees (16%, 37%, and 54%) of idealized membrane were built based on the Budd-Chiari syndrome vascular model using Geomagic software. Three membrane obstruction Budd-Chiari syndrome vascular models were established successfully and fluent software was used to simulate hemodynamic parameters, including blood velocity and wall shear stress. FINDINGS: The simulation results showed that there is low velocity and a low wall shear stress region at the junction of the inferior vena cava and the branches of the hepatic veins, and swirl may occur in this area. As the membrane develops, the size of the low velocity and low wall shear stress regions enlarged and the wall shear stress was increased at the membrane region. There was a significant difference in the mean values of wall shear stress between the different obstruction membrane models (P<0.05). INTERPRETATION: Hemodynamic parameters play an important role in vascular disease and there may be a correlation between inferior vena cava wall shear force changes and the slow development process of the inferior vena cava membrane.
BACKGROUND: This study was performed to determine the hemodynamic changes of Budd-Chiari syndrome when the inferior vena vein membrane is developing. METHODS: A patient-specific Budd-Chiari syndrome vascular model was reconstructed based on magnetic resonance images using Mimics software and different degrees (16%, 37%, and 54%) of idealized membrane were built based on the Budd-Chiari syndrome vascular model using Geomagic software. Three membrane obstruction Budd-Chiari syndrome vascular models were established successfully and fluent software was used to simulate hemodynamic parameters, including blood velocity and wall shear stress. FINDINGS: The simulation results showed that there is low velocity and a low wall shear stress region at the junction of the inferior vena cava and the branches of the hepatic veins, and swirl may occur in this area. As the membrane develops, the size of the low velocity and low wall shear stress regions enlarged and the wall shear stress was increased at the membrane region. There was a significant difference in the mean values of wall shear stress between the different obstruction membrane models (P<0.05). INTERPRETATION: Hemodynamic parameters play an important role in vascular disease and there may be a correlation between inferior vena cava wall shear force changes and the slow development process of the inferior vena cava membrane.