Yukiko Murata1, Katsunori Tatsugami2, Masahiro Yoshikawa1, Masumitsu Hamaguchi1, Shigetomo Yamada1, Yusuke Hayakawa1, Kouhei Ueda1, Seiya Momosaki3, Naotaka Sakamoto1,4. 1. Department of Urology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan. 2. Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, , Japan. 3. Department of Pathology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan. 4. Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Abstract
OBJECTIVE: To identify risk factors of biochemical recurrence after radical prostatectomy in high-risk patients. METHODS: A total of 191 high-risk prostate cancer patients according to the D'Amico classification treated with radical prostatectomy at a single institution between April 2000 and December 2013 were enrolled. The pathological evaluation including intraductal carcinoma of prostate was reassessed, and the clinical and pathological risk factors of biochemical recurrence were analyzed. RESULTS: The median follow up after radical prostatectomy was 49 months. The 5-year biochemical recurrence-free survival rate after radical prostatectomy in high-risk prostate cancer patients was 41.6%. Initial prostate-specific antigen, pathological Gleason score, seminal vesicle invasion, extraprostatic extension and intraductal carcinoma of the prostate were significantly associated with biochemical recurrence-free survival. The 5-year biochemical recurrence-free survival rates in patients with zero, one, two and three of these risk factors were 92.9%, 70.7%, 38.3% and 28.8%, respectively. In patients with four or more factors, the biochemical recurrence-free survival rate was 6.1% after 18 months. CONCLUSIONS: In D'Amico high-risk patients treated with radical prostatectomy, risk factors for biochemical recurrence can be identified. Patients with fewer risk factors have longer biochemical recurrence-free survival, even among these high-risk cases.
OBJECTIVE: To identify risk factors of biochemical recurrence after radical prostatectomy in high-risk patients. METHODS: A total of 191 high-risk prostate cancerpatients according to the D'Amico classification treated with radical prostatectomy at a single institution between April 2000 and December 2013 were enrolled. The pathological evaluation including intraductal carcinoma of prostate was reassessed, and the clinical and pathological risk factors of biochemical recurrence were analyzed. RESULTS: The median follow up after radical prostatectomy was 49 months. The 5-year biochemical recurrence-free survival rate after radical prostatectomy in high-risk prostate cancerpatients was 41.6%. Initial prostate-specific antigen, pathological Gleason score, seminal vesicle invasion, extraprostatic extension and intraductal carcinoma of the prostate were significantly associated with biochemical recurrence-free survival. The 5-year biochemical recurrence-free survival rates in patients with zero, one, two and three of these risk factors were 92.9%, 70.7%, 38.3% and 28.8%, respectively. In patients with four or more factors, the biochemical recurrence-free survival rate was 6.1% after 18 months. CONCLUSIONS: In D'Amico high-risk patients treated with radical prostatectomy, risk factors for biochemical recurrence can be identified. Patients with fewer risk factors have longer biochemical recurrence-free survival, even among these high-risk cases.
Authors: Łukasz Nyk; Hubert Kamecki; Wojciech Krajewski; Bartosz Małkiewicz; Tomasz Szydełko; Markiian Kubis; Marcin Słojewski; Piotr Kryst; Sławomir Poletajew; Wojciech Malewski Journal: Tomography Date: 2022-04-11
Authors: Natalia Vidal Crespo; Laura Enguita Arnal; Álvaro Gómez-Ferrer; Argimiro Collado Serra; Juan Manuel Mascarós; Ana Calatrava Fons; Juan Casanova Ramón-Borja; José Rubio Briones; Miguel Ramírez-Backhaus Journal: Medicina (Kaunas) Date: 2022-08-05 Impact factor: 2.948