Carmen Fiuza-Luces1,2, Jorge Díez-Bermejo3, Miguel Fernández-DE LA Torre1, Gabriel Rodríguez-Romo4, Paz Sanz-Ayán5, Aitor Delmiro1, Diego Munguía-Izquierdo6, Irene Rodríguez-Gómez7, Ignacio Ara7,8, Cristina Domínguez-González2,9, Joaquín Arenas1,2, Miguel A Martín1,2, Alejandro Lucia3,8, María Morán1,2. 1. Mitochondrial and Neuromuscular Diseases Laboratory, Research Institute of Hospital "12 de Octubre" ("i + 12"), Madrid, SPAIN. 2. Spanish Network for Biomedical Research in Rare Diseases (CIBERER), U723, SPAIN. 3. Department of Research and Doctorate Studies, European University, Madrid, SPAIN. 4. INEF. 5. Department of Rehabilitation Medicine, Research Institute of Hospital "12 de Octubre" ("i + 12"), Madrid, SPAIN. 6. Department of Sports and Computer Science, Section of Physical Education and Sports, Universidad Pablo de Olavide, Seville, SPAIN. 7. GENUD Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, SPAIN. 8. Spanish Network for Biomedical Research in Fragility and Healthy Aging (CIBERFES), SPAIN. 9. Neuromuscular Unit, Department of Neurology, Research Institute of Hospital "12 de Octubre" ("i + 12"), Madrid, SPAIN.
Abstract
PURPOSE: We determined the effects of an innovative 8-wk exercise intervention (aerobic, resistance, and inspiratory muscle training) for patients with mitochondrial disease. METHODS: Several end points were assessed in 12 patients (19-59 yr, 4 women) at pretraining, posttraining, and after 4-wk detraining: aerobic power, muscle strength/power and maximal inspiratory pressure (main end points), ability to perform activities of daily living, body composition, quality of life, and blood myokines (secondary end points). RESULTS: The program was safe, with patients' adherence being 94% ± 5%. A significant time effect was found for virtually all main end points (P ≤ 0.004), indicating a training improvement. Similar findings (P ≤ 0.003) were found for activities of daily living tests, total/trunk/leg lean mass, total fat mass, femoral fracture risk, and general health perception. No differences were found for blood myokines, except for an acute exertional increase in interleukin 8 at posttraining/detraining (P = 0.002) and in fatty acid binding protein 3 at detraining (P = 0.002). CONCLUSIONS: An intervention including novel exercises for mitochondrial disease patients (e.g., inspiratory muscle training) produced benefits in numerous indicators of physical capacity and induced a previously unreported shift toward a healthier body composition phenotype.
PURPOSE: We determined the effects of an innovative 8-wk exercise intervention (aerobic, resistance, and inspiratory muscle training) for patients with mitochondrial disease. METHODS: Several end points were assessed in 12 patients (19-59 yr, 4 women) at pretraining, posttraining, and after 4-wk detraining: aerobic power, muscle strength/power and maximal inspiratory pressure (main end points), ability to perform activities of daily living, body composition, quality of life, and blood myokines (secondary end points). RESULTS: The program was safe, with patients' adherence being 94% ± 5%. A significant time effect was found for virtually all main end points (P ≤ 0.004), indicating a training improvement. Similar findings (P ≤ 0.003) were found for activities of daily living tests, total/trunk/leg lean mass, total fat mass, femoral fracture risk, and general health perception. No differences were found for blood myokines, except for an acute exertional increase in interleukin 8 at posttraining/detraining (P = 0.002) and in fatty acid binding protein 3 at detraining (P = 0.002). CONCLUSIONS: An intervention including novel exercises for mitochondrial diseasepatients (e.g., inspiratory muscle training) produced benefits in numerous indicators of physical capacity and induced a previously unreported shift toward a healthier body composition phenotype.
Authors: Patrick M Schaefer; Komal Rathi; Arrienne Butic; Wendy Tan; Katherine Mitchell; Douglas C Wallace Journal: Proc Natl Acad Sci U S A Date: 2022-04-28 Impact factor: 12.779
Authors: Cristina Domínguez-González; Aurelio Hernández-Laín; Eloy Rivas; Ana Hernández-Voth; Javier Sayas Catalán; Roberto Fernández-Torrón; Carmen Fuiza-Luces; Jorge García García; Germán Morís; Montse Olivé; Frances Miralles; Jordi Díaz-Manera; Candela Caballero; Bosco Méndez-Ferrer; Ramon Martí; Elena García Arumi; María Carmen Badosa; Jesús Esteban; Cecilia Jimenez-Mallebrera; Alberto Blazquez Encinar; Joaquín Arenas; Michio Hirano; Miguel Ángel Martin; Carmen Paradas Journal: Orphanet J Rare Dis Date: 2019-05-06 Impact factor: 4.303
Authors: Carmen Fiuza-Luces; Pedro L Valenzuela; Sara Laine-Menéndez; Miguel Fernández-de la Torre; Verónica Bermejo-Gómez; Laura Rufián-Vázquez; Joaquín Arenas; Miguel A Martín; Alejandro Lucia; María Morán Journal: Front Neurol Date: 2019-07-25 Impact factor: 4.003
Authors: Miguel Fernández-de la Torre; Carmen Fiuza-Luces; Pedro L Valenzuela; Sara Laine-Menéndez; Joaquín Arenas; Miguel A Martín; Doug M Turnbull; Alejandro Lucia; María Morán Journal: Front Physiol Date: 2020-12-08 Impact factor: 4.566
Authors: Sara Laine-Menéndez; Miguel Fernández-de la Torre; Carmen Fiuza-Luces; Aitor Delmiro; Joaquín Arenas; Miguel Ángel Martín; Patricia Boya; Alejandro Lucia; María Morán Journal: Antioxidants (Basel) Date: 2022-03-07