Literature DB >> 29314004

Role of Wnt signalling in advanced prostate cancer.

Imran Ahmad1,2, Owen J Sansom1,2.   

Abstract

Recent next-generation sequencing studies demonstrate that multiple pathways are often deregulated in advanced and metastatic prostate cancer (PC). In a recent issue of The Journal of Pathology, an elegant study by Jefferies et al used in vivo modelling to demonstrate how activation of the PI3K, WNT, and MAPK pathway converges on mTORC1 signalling to drive aggressive disease. The study also highlights that approaches to target advanced PC require intelligent combination of agents to target single/multiple signalling pathways in combination with androgen receptor (AR) blockade.
Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Entities:  

Keywords:  Wnt signalling; prostate cancer

Mesh：

Substances：

Year:  2018        PMID： 29314004     DOI： 10.1002/path.5029

Source DB:  PubMed          Journal:  J Pathol        ISSN： 0022-3417            Impact factor:   7.996


  6 in total

1.  miR-425-5p suppresses tumorigenesis and DDP resistance in human-prostate cancer by targeting GSK3β and inactivating the Wnt/β-catenin signaling pathway.

Authors:  Sheng Liu; Qin Wang; Yin Liu; Zong-Yu Xia
Journal:  J Biosci       Date:  2019-09       Impact factor: 1.826

Review 2.  The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling.

Authors:  Boris Y Shorning; Manisha S Dass; Matthew J Smalley; Helen B Pearson
Journal:  Int J Mol Sci       Date:  2020-06-25       Impact factor: 5.923

3.  Identification of aberrantly methylated differentially expressed genes in prostate carcinoma using integrated bioinformatics.

Authors:  Kai Wu; Xiaotao Yin; Yipeng Jin; Fangfang Liu; Jiangping Gao
Journal:  Cancer Cell Int       Date:  2019-03-05       Impact factor: 5.722

4.  Gene Panel of Persister Cells as a Prognostic Indicator for Tumor Repopulation After Radiation.

Authors:  Yucui Zhao; Yanwei Song; Ruyi Zhao; Minghui Zhao; Qian Huang
Journal:  Front Oncol       Date:  2020-11-20       Impact factor: 6.244

5.  The Glypican proteoglycans show intrinsic interactions with Wnt-3a in human prostate cancer cells that are not always associated with cascade activation.

Authors:  Gabrielle Ferrante Alves de Moraes; Eduardo Listik; Giselle Zenker Justo; Carolina Meloni Vicente; Leny Toma
Journal:  BMC Mol Cell Biol       Date:  2021-05-04

6.  Anethole induces anti-oral cancer activity by triggering apoptosis, autophagy and oxidative stress and by modulation of multiple signaling pathways.

Authors:  Camille Contant; Mahmoud Rouabhia; Lionel Loubaki; Fatiha Chandad; Abdelhabib Semlali
Journal:  Sci Rep       Date:  2021-06-22       Impact factor: 4.379
  6 in total

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