Literature DB >> 29313219

Neurotoxins as Preclinical Models for Parkinson's Disease.

Juan Segura-Aguilar1.   

Abstract

Translational medicine is one of the major concerns in this century. While significant advances have been made with scientific knowledge, the translation of their promising results has not led to any new therapies. In Parkinson's disease, a long list of clinical studies, based on preclinical models with exogenous neurotoxins, has failed. Therefore, the aim of this opinion paper is to open discussion about preclinical models for Parkinson's disease based on neurotoxins.

Entities:  

Keywords:  6-Hydroxydopamine; Aminochrome; Clinical studies; Dopamine; MPTP; Neurodegeneration; Neurotoxins; Parkinson’s disease; Preclinical models; Rotenon; Translational medicine

Mesh：

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Year:  2018        PMID： 29313219     DOI： 10.1007/s12640-017-9856-0

Source DB:  PubMed          Journal:  Neurotox Res        ISSN： 1029-8428            Impact factor:   3.911


  109 in total

1.  FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease.

Authors:  Anke Van der Perren; Francesca Macchi; Jaan Toelen; Marianne S Carlon; Michael Maris; Henriette de Loor; Dirk R J Kuypers; Rik Gijsbers; Chris Van den Haute; Zeger Debyser; Veerle Baekelandt
Journal:  Neurobiol Aging       Date:  2015-01-21       Impact factor: 4.673

2.  DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity.

Authors:  Patricia Muñoz; Sergio Cardenas; Sandro Huenchuguala; Andrea Briceño; Eduardo Couve; Irmgard Paris; Juan Segura-Aguilar
Journal:  Toxicol Sci       Date:  2015-01-28       Impact factor: 4.849

3.  DT-diaphorase protects astrocytes from aminochrome-induced toxicity.

Authors:  Sandro Huenchuguala; Patricia Muñoz; Rebecca Graumann; Irmgard Paris; Juan Segura-Aguilar
Journal:  Neurotoxicology       Date:  2016-05-07       Impact factor: 4.294

4.  Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL).

Authors:  Cristian Follmer; Eduardo Coelho-Cerqueira; Danilo Y Yatabe-Franco; Gabriel D T Araujo; Anderson S Pinheiro; Gilberto B Domont; David Eliezer
Journal:  J Biol Chem       Date:  2015-09-17       Impact factor: 5.157

5.  Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction.

Authors:  Sandro Huenchuguala; Patricia Muñoz; Patricio Zavala; Mónica Villa; Carlos Cuevas; Ulises Ahumada; Rebecca Graumann; Beston F Nore; Eduardo Couve; Bengt Mannervik; Irmgard Paris; Juan Segura-Aguilar
Journal:  Autophagy       Date:  2014-01-14       Impact factor: 16.016

Review 6.  Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance.

Authors:  Dena G Hernandez; Xylena Reed; Andrew B Singleton
Journal:  J Neurochem       Date:  2016-04-18       Impact factor: 5.372

7.  Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4.

Authors:  David N Hauser; April A Dukes; Amanda D Mortimer; Teresa G Hastings
Journal:  Free Radic Biol Med       Date:  2013-06-28       Impact factor: 7.376

Review 8.  The neuromelanin of human substantia nigra and its interaction with metals.

Authors:  L Zecca; D Tampellini; A Gatti; R Crippa; M Eisner; D Sulzer; S Ito; R Fariello; M Gallorini
Journal:  J Neural Transm (Vienna)       Date:  2002-05       Impact factor: 3.575

9.  Inhibition of VMAT-2 and DT-diaphorase induce cell death in a substantia nigra-derived cell line--an experimental cell model for dopamine toxicity studies.

Authors:  Patricio Fuentes; Irmgard Paris; Melissa Nassif; Pablo Caviedes; Juan Segura-Aguilar
Journal:  Chem Res Toxicol       Date:  2007-04-11       Impact factor: 3.739

Review 10.  Genetic Determinants of Parkinson's Disease: Can They Help to Stratify the Patients Based on the Underlying Molecular Defect?

Authors:  Sara Redenšek; Maja Trošt; Vita Dolžan
Journal:  Front Aging Neurosci       Date:  2017-02-10       Impact factor: 5.750
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  7 in total

1.  JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species.

Authors:  Cleonice Creusa Santos; Thyago R Cardim-Pires; Liana Shvachiy; Luis Arturo Fonseca-Fonseca; Patricia Muñoz; Áurea Maria A N Almeida; Ana Carla S Costa; Jéssica Teles-Souza; Estael Ochoa-Rodríguez; Maria de Fátima Dias Costa; Fernando L Palhano; Juan Segura-Aguilar; Deyse B Barbosa; Mayra R do Bomfim; Manoelito C Dos Santos Junior; Franco Henrique A Leite; Samuel Silva da Rocha Pita; Silvia Lima Costa; Yanier Núñez-Figueredo; Tiago Fleming Outeiro; Débora Foguel; Victor Diogenes Amaral Silva
Journal:  Neurotox Res       Date:  2022-08-23       Impact factor: 3.978

2.  Protective Effects of Crude Plant Extracts against Aminochrome-induced toxicity in Human Astrocytoma Cells: Implications for Parkinson's Disease.

Authors:  Viviane L Ndam Ngoungoure; Patricia Muñoz; Yousef Tizabi; Raul Valdes; Paul Fewou Moundipa; Juan Segura-Aguilar
Journal:  Clin Pharmacol Transl Med       Date:  2019-04-08

3.  Cytoprotective Activity of p-Terphenyl Polyketides and Flavuside B from Marine-Derived Fungi against Oxidative Stress in Neuro-2a Cells.

Authors:  Ekaterina A Yurchenko; Ekaterina S Menchinskaya; Evgeny A Pislyagin; Ekaterina A Chingizova; Elena V Girich; Anton N Yurchenko; Dmitry L Aminin; Valery V Mikhailov
Journal:  Molecules       Date:  2021-06-13       Impact factor: 4.411

4.  Can we conclude a potential therapeutic action for Parkinson's disease by using postmortem tissue and a preclinical model based on an exogenous neurotoxin?

Authors:  Juan Segura-Aguilar
Journal:  Cell Death Dis       Date:  2018-07-03       Impact factor: 8.469

Review 5.  Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins.

Authors:  Yanlu Cao; Bo Li; Nafissa Ismail; Kevin Smith; Tianmei Li; Rongji Dai; Yulin Deng
Journal:  Int J Mol Sci       Date:  2021-11-26       Impact factor: 5.923

6.  Intrapallidal injection of cannabidiol or a selective GPR55 antagonist decreases motor asymmetry and improves fine motor skills in hemiparkinsonian rats.

Authors:  Felipe Patricio; Eliud Morales Dávila; Aleidy Patricio-Martínez; Nayeli Arana Del Carmen; Isabel Martínez; José Aguilera; Jose Manuel Perez-Aguilar; Ilhuicamina Daniel Limón
Journal:  Front Pharmacol       Date:  2022-09-02       Impact factor: 5.988

7.  Lanostane Triterpenoid Metabolites from a Penares sp. Marine Sponge Protect Neuro-2a Cells against Paraquat Neurotoxicity.

Authors:  Ekaterina A Yurchenko; Sophia A Kolesnikova; Ekaterina G Lyakhova; Ekaterina S Menchinskaya; Evgeny A Pislyagin; Ekaterina A Chingizova; Dmitry L Aminin
Journal:  Molecules       Date:  2020-11-18       Impact factor: 4.411
  7 in total

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