Literature DB >> 2931302

Effect of testosterone on the kinetics of the development of suppressor cells in adjuvant arthritis.

M Tsukano, M Kotani, K Matsuno, K Miyakawa, Y Nawa.   

Abstract

The induction of unresponsiveness to mycobacterial adjuvant took a longer time in male DA rats than in female rats. A shift in the induction time of unresponsiveness in males toward the female type was brought about by castration, but could be reverted to the male type by the application of testosterone. The transfer study revealed that cells capable of preventing arthritis required a longer incubation time for their development in males than in females. This suggests that testosterone inhibits the development of suppressor cells in adjuvant arthritis.

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Year:  1985        PMID： 2931302     DOI： 10.1007/BF01952083

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  Passive transfer of unresponsiveness by lymph node cells. Studies on adjuvant disease.

Authors:  E M Eugui; R H Houssay
Journal:  Immunology       Date:  1975-04       Impact factor: 7.397

2.  Characterization of low dose induced suppressor cells in adjuvant arthritis in rats.

Authors:  M Tsukano; Y Nawa; M Kotani
Journal:  Clin Exp Immunol       Date:  1983-07       Impact factor: 4.330

3.  Susceptibility to adjuvant arthritis in DA and F344 rats. A dominant trait controlled by an autosomal gene locus linked to the major histocompatibility complex.

Authors:  J R Battisto; R N Smith; K Beckman; M Sternlicht; W L Welles
Journal:  Arthritis Rheum       Date:  1982-10

4.  Influence of the composition of Freund's adjuvant, strain and sex of animals on the course of adjuvant--induced polyarthritis in rats.

Authors:  A Ryzewska
Journal:  Reumatologia       Date:  1969

5.  Adjuvant-induced polyarthritis in rats: biologic and histologic background.

Authors:  E M Glenn; J Gray
Journal:  Am J Vet Res       Date:  1965-09       Impact factor: 1.156

6.  Immunogenetic control of experimental type II collagen-induced arthritis. I. Susceptibility and resistance among inbred strains of rats.

Authors:  M M Griffiths; E J Eichwald; J H Martin; C B Smith; C W DeWitt
Journal:  Arthritis Rheum       Date:  1981-06

7.  Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice.

Authors:  A D Steinberg; J B Roths; E D Murphy; R T Steinberg; E S Raveche
Journal:  J Immunol       Date:  1980-08       Impact factor: 5.422

8.  Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice.

Authors:  J R Roubinian; N Talal; J S Greenspan; J R Goodman; P K Siiteri
Journal:  J Exp Med       Date:  1978-06-01       Impact factor: 14.307
  8 in total

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