Attila Nemes1, Imelda Marton2, Péter Domsik1, Anita Kalapos1, Éva Pósfai2, Szabolcs Modok2, Zita Borbényi1, Tamás Forster1. 1. 2nd Department of Medicine and Cardiology Centre, 2nd Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary. 2. Division of Haematology, 2nd Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
Abstract
BACKGROUND: Persistent eosinophilia and eosinophil-mediated single- or multiple-organ damage are typical features of hypereosinophilic syndrome (HES). Theoretically, eosinophilic infiltration of the ascending aortic wall could not be excluded in HES, therefore the present study aimed to test whether HES is associated with abnormalities in aortic elastic properties. METHODS: The present study comprised 10 HES patients (mean age: 57.6±10.1 years, 5 males) without known cardiovascular disease, their results were compared to 19 age-, gender- and risk factor-matched controls (59.2±4.2 years, 15 males). Complete two-dimensional Doppler echocardiography with measurement of echocardiographic aortic elastic properties was performed in all HES cases and controls. RESULTS: Although neither systolic (30.6±3.4 vs. 30.1±3.6 mm, P=ns), nor diastolic (28.7±3.6 vs. 27.8±3.2 mm, P=ns) aortic diameter differed significantly between HES patients and matched controls, significantly increased aortic stiffness index (11.19±5.65 vs. 7.04±2.97, P<0.05) could be demonstrated in HES patients. CONCLUSIONS: Increased aortic stiffness could be demonstrated in HES patients in their early necrotic phase.
BACKGROUND: Persistent eosinophilia and eosinophil-mediated single- or multiple-organ damage are typical features of hypereosinophilic syndrome (HES). Theoretically, eosinophilic infiltration of the ascending aortic wall could not be excluded in HES, therefore the present study aimed to test whether HES is associated with abnormalities in aortic elastic properties. METHODS: The present study comprised 10 HES patients (mean age: 57.6±10.1 years, 5 males) without known cardiovascular disease, their results were compared to 19 age-, gender- and risk factor-matched controls (59.2±4.2 years, 15 males). Complete two-dimensional Doppler echocardiography with measurement of echocardiographic aortic elastic properties was performed in all HES cases and controls. RESULTS: Although neither systolic (30.6±3.4 vs. 30.1±3.6 mm, P=ns), nor diastolic (28.7±3.6 vs. 27.8±3.2 mm, P=ns) aortic diameter differed significantly between HES patients and matched controls, significantly increased aortic stiffness index (11.19±5.65 vs. 7.04±2.97, P<0.05) could be demonstrated in HES patients. CONCLUSIONS: Increased aortic stiffness could be demonstrated in HES patients in their early necrotic phase.
Authors: T Kleinfeldt; C A Nienaber; S Kische; I Akin; R G Turan; T Körber; H Schneider; H Ince Journal: Clin Res Cardiol Date: 2010-03-24 Impact factor: 5.460
Authors: Attila Nemes; Marcel L Geleijnse; Tamás Forster; Osama I I Soliman; Folkert J Ten Cate; Miklós Csanády Journal: Clin Cardiol Date: 2008-07 Impact factor: 2.882