Ying Liang1, Yahong Chen1, Rui Wu1, Ming Lu1, Wanzhen Yao1, Jian Kang2, Baiqiang Cai3, Xin Zhou4, Zheng Liu5, Ping Chen6, Dejun Sun7, Jingping Zheng8, Guoyang Wang9, Yulin Feng10, Yongjian Xu11. 1. Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China. 2. Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, First Hospital of China Medical University, Shenyang 110000, China. 3. Pulmonary and Critical Care Medicine, Peking Union Hospital, Beijing 100000, China. 4. Pulmonary and Critical Care Medicine, Shanghai First People's Hospital, Shanghai 20000, China. 5. Pulmonary and Critical Care Medicine, China Oil and Gas Group Central Hospital, Langfang 065000, China. 6. Pulmonary and Critical Care Medicine, The General Hospital of Shenyang Military Region of PLA, Shenyang 110000, China. 7. Pulmonary and Critical Care Medicine, Inner Mongolia People's Hospital, Hohhot 010000, China. 8. State Key Lab. of Respiratory Disease, Guangzhou Institute of Respiratory Disease, Guangzhou 510000, China. 9. Pulmonary and Critical Care Medicine, Beijing Jingmei Group General Hospital, Beijing 100000, China. 10. Pulmonary and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu 610000, China. 11. Pulmonary and Critical Care Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430000, China.
Abstract
BACKGROUND: Chronic bronchitis (CB) is closely associated with the frequency and severity of chronic obstructive pulmonary disease (COPD) exacerbation. However, little is known about the impact of CB on COPD exacerbations, severe and non-severe, and on recovery from an exacerbation. METHODS: We conducted a nation-wide multicenter cross-sectional survey in China between September 2007 and December 2008. Eleven hospitals participated in this study. Patients' demographic information, presence of CB, overall numbers of COPD exacerbation and severe exacerbation leading to emergency visit, hospitalization and intensive care unit (ICU) stay in the past year, recovery period following the last exacerbation, and well- or poor-recovery were recorded. RESULTS: A total of 1,101 patients with COPD were enrolled and 890 (80.8%) had CB. Patients with CB reported more history of frequent exacerbations (≥2/patient/year) (59.6% vs. 50.7%, P=0.019) and severe exacerbation (% emergency visit ≥1: 28.0% vs. 16.6%, P=0.001; % hospitalization ≥1: 51.2% vs. 28.0%, P<0.001; %ICU stay ≥1: 6.5% vs. 1.9%, P=0.009). Recovery period following the last exacerbation was longer in patients with CB (19.0±16.2 vs. 15.2±14.7 days, P=0.003) and more patients with CB reported poor recovery (85.8% vs. 78.4%, P=0.003). Multivariate analyses showed that CB was independently associated with severe exacerbation requiring emergency visit (adjusted OR, 1.512, P=0.048) and hospitalization (adjusted OR, 2.031, P<0.001) and prolonged recovery period (adjusted regression coefficient 2.861, P=0.030). CONCLUSIONS: CB is associated with frequent exacerbations of COPD in Chinese population, especially severe exacerbations requiring emergency visit and hospitalization admission. Additionally, CB significantly prolongs recovery period following COPD exacerbation.
BACKGROUND: Chronic bronchitis (CB) is closely associated with the frequency and severity of chronic obstructive pulmonary disease (COPD) exacerbation. However, little is known about the impact of CB on COPD exacerbations, severe and non-severe, and on recovery from an exacerbation. METHODS: We conducted a nation-wide multicenter cross-sectional survey in China between September 2007 and December 2008. Eleven hospitals participated in this study. Patients' demographic information, presence of CB, overall numbers of COPD exacerbation and severe exacerbation leading to emergency visit, hospitalization and intensive care unit (ICU) stay in the past year, recovery period following the last exacerbation, and well- or poor-recovery were recorded. RESULTS: A total of 1,101 patients with COPD were enrolled and 890 (80.8%) had CB. Patients with CB reported more history of frequent exacerbations (≥2/patient/year) (59.6% vs. 50.7%, P=0.019) and severe exacerbation (% emergency visit ≥1: 28.0% vs. 16.6%, P=0.001; % hospitalization ≥1: 51.2% vs. 28.0%, P<0.001; %ICU stay ≥1: 6.5% vs. 1.9%, P=0.009). Recovery period following the last exacerbation was longer in patients with CB (19.0±16.2 vs. 15.2±14.7 days, P=0.003) and more patients with CB reported poor recovery (85.8% vs. 78.4%, P=0.003). Multivariate analyses showed that CB was independently associated with severe exacerbation requiring emergency visit (adjusted OR, 1.512, P=0.048) and hospitalization (adjusted OR, 2.031, P<0.001) and prolonged recovery period (adjusted regression coefficient 2.861, P=0.030). CONCLUSIONS: CB is associated with frequent exacerbations of COPD in Chinese population, especially severe exacerbations requiring emergency visit and hospitalization admission. Additionally, CB significantly prolongs recovery period following COPD exacerbation.
Authors: Maria Montes de Oca; Ronald J Halbert; Maria Victorina Lopez; Rogelio Perez-Padilla; Carlos Tálamo; Dolores Moreno; Adrianna Muiño; José Roberto B Jardim; Gonzalo Valdivia; Julio Pertuzé; Ana Maria B Menezes Journal: Eur Respir J Date: 2012-01-26 Impact factor: 16.671
Authors: Lorcan McGarvey; Amanda J Lee; June Roberts; Kevin Gruffydd-Jones; Eddie McKnight; John Haughney Journal: Respir Med Date: 2014-12-30 Impact factor: 3.415
Authors: T A Seemungal; G C Donaldson; E A Paul; J C Bestall; D J Jeffries; J A Wedzicha Journal: Am J Respir Crit Care Med Date: 1998-05 Impact factor: 21.405
Authors: Ya-Hong Chen; Wan-Zhen Yao; Jian Kang; Bai-Qiang Cai; Xin Zhou; Zheng Liu; Ping Chen; De-Jun Sun; Jing-Ping Zheng; Guo-Yang Wang; Yu-Lin Feng; Yong-Jian Xu; Yan Jia; Ming Lu; Chun Chang; Xiao-Hong Wang Journal: Zhonghua Jie He He Hu Xi Za Zhi Date: 2010-10
Authors: Wilhelmine H Meeraus; Bailey M DeBarmore; Hana Mullerova; William A Fahy; Victoria S Benson Journal: Int J Chron Obstruct Pulmon Dis Date: 2021-12-24