Literature DB >> 29311131

Posttranslational Modifications of RAS Proteins.

Ian Ahearn1, Mo Zhou1, Mark R Philips1.   

Abstract

The three human RAS genes encode four proteins that play central roles in oncogenesis by acting as binary molecular switches that regulate signaling pathways for growth and differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify their activity or are required for membrane targeting. The enzymes that catalyze the various PTMs are potential targets for anti-RAS drug discovery. The PTMs of RAS proteins are the focus of this review.
Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2018        PMID： 29311131      PMCID： PMC6035883          DOI： 10.1101/cshperspect.a031484

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN： 2157-1422            Impact factor:   6.915


  164 in total

1.  Compartmentalized signaling of Ras in fission yeast.

Authors:  Brian Onken; Heidi Wiener; Mark R Philips; Eric C Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-05       Impact factor: 11.205

2.  A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS).

Authors:  J A Duncan; A G Gilman
Journal:  J Biol Chem       Date:  1998-06-19       Impact factor: 5.157

3.  Palmitoylation of oncogenic NRAS is essential for leukemogenesis.

Authors:  Benjamin Cuiffo; Ruibao Ren
Journal:  Blood       Date:  2010-03-03       Impact factor: 22.113

Review 4.  Drugging the undruggable RAS: Mission possible?

Authors:  Adrienne D Cox; Stephen W Fesik; Alec C Kimmelman; Ji Luo; Channing J Der
Journal:  Nat Rev Drug Discov       Date:  2014-10-17       Impact factor: 84.694

5.  Probing the role of loop 2 in Ras function with unnatural amino acids.

Authors:  H H Chung; D R Benson; V W Cornish; P G Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205

Review 6.  Structural determinants of protein partitioning into ordered membrane domains and lipid rafts.

Authors:  Joseph Helmuth Lorent; Ilya Levental
Journal:  Chem Phys Lipids       Date:  2015-08-01       Impact factor: 3.329

7.  The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins.

Authors:  C A Hrycyna; S K Sapperstein; S Clarke; S Michaelis
Journal:  EMBO J       Date:  1991-07       Impact factor: 11.598

8.  Dynamic fatty acylation of p21N-ras.

Authors:  A I Magee; L Gutierrez; I A McKay; C J Marshall; A Hall
Journal:  EMBO J       Date:  1987-11       Impact factor: 11.598

9.  Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway.

Authors:  J Shawn Goodwin; Kimberly R Drake; Carl Rogers; Latasha Wright; Jennifer Lippincott-Schwartz; Mark R Philips; Anne K Kenworthy
Journal:  J Cell Biol       Date:  2005-07-18       Impact factor: 10.539

10.  A comprehensive survey of Ras mutations in cancer.

Authors:  Ian A Prior; Paul D Lewis; Carla Mattos
Journal:  Cancer Res       Date:  2012-05-15       Impact factor: 12.701
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  24 in total

Review 1.  Mechanistic and Preclinical Insights from Mouse Models of Hematologic Cancer Characterized by Hyperactive Ras.

Authors:  Anica Wandler; Kevin Shannon
Journal:  Cold Spring Harb Perspect Med       Date:  2018-04-02       Impact factor: 6.915

Review 2.  Regulation of large and small G proteins by ubiquitination.

Authors:  Henrik G Dohlman; Sharon L Campbell
Journal:  J Biol Chem       Date:  2019-10-23       Impact factor: 5.157

3.  Organization of Farnesylated, Carboxymethylated KRAS4B on Membranes.

Authors:  Eric Barklis; Andrew G Stephen; August O Staubus; Robin Lid Barklis; Ayna Alfadhli
Journal:  J Mol Biol       Date:  2019-07-19       Impact factor: 5.469

4.  Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association.

Authors:  Mo Zhou; Leena Kuruvilla; Xiarong Shi; Stephen Viviano; Ian M Ahearn; Caroline R Amendola; Wenjuan Su; Sana Badri; James Mahaffey; Nicole Fehrenbacher; Jane Skok; Joseph Schlessinger; Benjamin E Turk; David A Calderwood; Mark R Philips
Journal:  Proc Natl Acad Sci U S A       Date:  2020-11-30       Impact factor: 11.205

5.  Regulation of GTPase function by autophosphorylation.

Authors:  Christian W Johnson; Hyuk-Soo Seo; Elizabeth M Terrell; Moon-Hee Yang; Fenneke KleinJan; Teklab Gebregiworgis; Genevieve M C Gasmi-Seabrook; Ezekiel A Geffken; Jimit Lakhani; Kijun Song; Puspalata Bashyal; Olesja Popow; Joao A Paulo; Andrea Liu; Carla Mattos; Christopher B Marshall; Mitsuhiko Ikura; Deborah K Morrison; Sirano Dhe-Paganon; Kevin M Haigis
Journal:  Mol Cell       Date:  2022-02-23       Impact factor: 17.970

6.  Mutation bias within oncogene families is related to proliferation-specific codon usage.

Authors:  Hannah Benisty; Marc Weber; Xavier Hernandez-Alias; Martin H Schaefer; Luis Serrano
Journal:  Proc Natl Acad Sci U S A       Date:  2020-11-16       Impact factor: 11.205

Review 7.  Small-Molecule Therapeutic Perspectives for the Treatment of Progeria.

Authors:  Jon Macicior; Beatriz Marcos-Ramiro; Silvia Ortega-Gutiérrez
Journal:  Int J Mol Sci       Date:  2021-07-03       Impact factor: 5.923

8.  Identification of lysine methylation in the core GTPase domain by GoMADScan.

Authors:  Hirofumi Yoshino; Guowei Yin; Risa Kawaguchi; Konstantin I Popov; Brenda Temple; Mika Sasaki; Satoshi Kofuji; Kara Wolfe; Kaori Kofuji; Koichi Okumura; Jaskirat Randhawa; Akshiv Malhotra; Nazanin Majd; Yoshiki Ikeda; Hiroko Shimada; Emily Rose Kahoud; Sasson Haviv; Shigeki Iwase; John M Asara; Sharon L Campbell; Atsuo T Sasaki
Journal:  PLoS One       Date:  2019-08-07       Impact factor: 3.240

Review 9.  The Hypervariable Region of K-Ras4B Governs Molecular Recognition and Function.

Authors:  Hazem Abdelkarim; Avik Banerjee; Patrick Grudzien; Nicholas Leschinsky; Mahmoud Abushaer; Vadim Gaponenko
Journal:  Int J Mol Sci       Date:  2019-11-14       Impact factor: 5.923

Review 10.  Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification.

Authors:  Natsuki Osaka; Yoshihisa Hirota; Doshun Ito; Yoshiki Ikeda; Ryo Kamata; Yuki Fujii; Venkat R Chirasani; Sharon L Campbell; Koh Takeuchi; Toshiya Senda; Atsuo T Sasaki
Journal:  Front Mol Biosci       Date:  2021-07-08
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