| Literature DB >> 29310081 |
Hamed Nosrati1, Naser Sefidi2, Ali Sharafi3, Hossein Danafar4, Hamidreza Kheiri Manjili5.
Abstract
The bovine serum albumin-coated magnetic nanoparticles (F@BSA NPs) were prepared as curcumin (CUR) carriers through desolvation and chemical co-precipitation process. The characteristics of CUR loaded F@BSA NPs (F@BSA@CUR NPs) were determined by X-ray diffraction (XRD), thermogravimetric analysis (TGA), fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and vibrating-sampling magnetometry (VSM) techniques. It was found that the synthesized F@BSA@CUR NPs were spherical in shape with an average size of 56 ± 11.43 nm (mean ± SD (n = 33)), ζ-potential of -10.1 mV, and good magnetic responsivity. Meanwhile, the drug content of the nanoparticles was 6.88%. These F@BSA@CUR NPs also demonstrated sustained release of CUR at 37 °C in different buffer solutions. Cellular toxicity of F@BSA@CUR NPs was studied on HFF2 cell line. Also, the cytotoxicity of F@BSA@CUR NPs towards MCF-7 breast cancer cells was investigated. The results revealed that F@BSA@CUR NPs have significant cytotoxicity activity on MCF-7 cell line.Entities:
Keywords: Albumin nanoparticles; BSA coated Fe(3)O(4); Bovine Serum Albumin (BSA); Curcumin; Drug delivery; Magnetic nanoparticles
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Year: 2018 PMID： 29310081 DOI： 10.1016/j.bioorg.2017.12.033
Source DB: PubMed Journal: Bioorg Chem ISSN： 0045-2068 Impact factor: 5.275